node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNMBP | MACC1 | ENSPPYP00000002971 | ENSPPYP00000019895 | DNMBP isoform 3. | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | 0.883 |
DNMBP | MDC1 | ENSPPYP00000002971 | ENSPPYP00000018356 | DNMBP isoform 3. | MDC1 isoform 1. | 0.872 |
DNMBP | RRS1 | ENSPPYP00000002971 | ENSPPYP00000020904 | DNMBP isoform 3. | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. | 0.918 |
DNMBP | SIX3 | ENSPPYP00000002971 | ENSPPYP00000013901 | DNMBP isoform 3. | SIX3 isoform 1. | 0.853 |
EPS15 | HGF | ENSPPYP00000001582 | ENSPPYP00000020015 | Epidermal growth factor receptor pathway substrate 15. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.556 |
EPS15 | MACC1 | ENSPPYP00000001582 | ENSPPYP00000019895 | Epidermal growth factor receptor pathway substrate 15. | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | 0.474 |
EPS15 | MET | ENSPPYP00000001582 | ENSPPYP00000020106 | Epidermal growth factor receptor pathway substrate 15. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.497 |
HGF | EPS15 | ENSPPYP00000020015 | ENSPPYP00000001582 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Epidermal growth factor receptor pathway substrate 15. | 0.556 |
HGF | MACC1 | ENSPPYP00000020015 | ENSPPYP00000019895 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | 0.647 |
HGF | MET | ENSPPYP00000020015 | ENSPPYP00000020106 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.999 |
MACC1 | DNMBP | ENSPPYP00000019895 | ENSPPYP00000002971 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | DNMBP isoform 3. | 0.883 |
MACC1 | EPS15 | ENSPPYP00000019895 | ENSPPYP00000001582 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | Epidermal growth factor receptor pathway substrate 15. | 0.474 |
MACC1 | HGF | ENSPPYP00000019895 | ENSPPYP00000020015 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.647 |
MACC1 | MDC1 | ENSPPYP00000019895 | ENSPPYP00000018356 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | MDC1 isoform 1. | 0.865 |
MACC1 | MET | ENSPPYP00000019895 | ENSPPYP00000020106 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.614 |
MACC1 | RRS1 | ENSPPYP00000019895 | ENSPPYP00000020904 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. | 0.883 |
MACC1 | SIX3 | ENSPPYP00000019895 | ENSPPYP00000013901 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | SIX3 isoform 1. | 0.841 |
MDC1 | DNMBP | ENSPPYP00000018356 | ENSPPYP00000002971 | MDC1 isoform 1. | DNMBP isoform 3. | 0.872 |
MDC1 | MACC1 | ENSPPYP00000018356 | ENSPPYP00000019895 | MDC1 isoform 1. | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. | 0.865 |
MDC1 | RRS1 | ENSPPYP00000018356 | ENSPPYP00000020904 | MDC1 isoform 1. | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. | 0.868 |