| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGMO | AK4 | ENSPPYP00000019918 | ENSPPYP00000001480 | AGMO isoform 1; Belongs to the sterol desaturase family. | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular r [...] | 0.503 |
| AGMO | ALDH3A2 | ENSPPYP00000019918 | ENSPPYP00000023716 | AGMO isoform 1; Belongs to the sterol desaturase family. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.750 |
| AGMO | ARHGAP6 | ENSPPYP00000019918 | ENSPPYP00000022506 | AGMO isoform 1; Belongs to the sterol desaturase family. | ARHGAP6 isoform 1. | 0.569 |
| AGMO | CPZ | ENSPPYP00000019918 | ENSPPYP00000016268 | AGMO isoform 1; Belongs to the sterol desaturase family. | Carboxypeptidase Z isoform X1. | 0.569 |
| AGMO | DCTD | ENSPPYP00000019918 | ENSPPYP00000017005 | AGMO isoform 1; Belongs to the sterol desaturase family. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.657 |
| AGMO | FA2H | ENSPPYP00000019918 | ENSPPYP00000008525 | AGMO isoform 1; Belongs to the sterol desaturase family. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.718 |
| AGMO | ISPD | ENSPPYP00000019918 | ENSPPYP00000019916 | AGMO isoform 1; Belongs to the sterol desaturase family. | Uncharacterized protein. | 0.513 |
| AGMO | MEOX2 | ENSPPYP00000019918 | ENSPPYP00000019917 | AGMO isoform 1; Belongs to the sterol desaturase family. | Mesenchyme homeobox 2. | 0.511 |
| AGMO | PNMT | ENSPPYP00000019918 | ENSPPYP00000009529 | AGMO isoform 1; Belongs to the sterol desaturase family. | PNMT isoform 2. | 0.545 |
| AGMO | SORBS3 | ENSPPYP00000019918 | ENSPPYP00000020645 | AGMO isoform 1; Belongs to the sterol desaturase family. | SORBS3 isoform 3. | 0.569 |
| AK4 | AGMO | ENSPPYP00000001480 | ENSPPYP00000019918 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular r [...] | AGMO isoform 1; Belongs to the sterol desaturase family. | 0.503 |
| AK4 | ARHGAP6 | ENSPPYP00000001480 | ENSPPYP00000022506 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular r [...] | ARHGAP6 isoform 1. | 0.492 |
| AK4 | DCTD | ENSPPYP00000001480 | ENSPPYP00000017005 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular r [...] | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.658 |
| ALDH3A2 | AGMO | ENSPPYP00000023716 | ENSPPYP00000019918 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | AGMO isoform 1; Belongs to the sterol desaturase family. | 0.750 |
| ALDH3A2 | FA2H | ENSPPYP00000023716 | ENSPPYP00000008525 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.515 |
| ARHGAP6 | AGMO | ENSPPYP00000022506 | ENSPPYP00000019918 | ARHGAP6 isoform 1. | AGMO isoform 1; Belongs to the sterol desaturase family. | 0.569 |
| ARHGAP6 | AK4 | ENSPPYP00000022506 | ENSPPYP00000001480 | ARHGAP6 isoform 1. | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular r [...] | 0.492 |
| ARHGAP6 | DCTD | ENSPPYP00000022506 | ENSPPYP00000017005 | ARHGAP6 isoform 1. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.658 |
| ARHGAP6 | SORBS3 | ENSPPYP00000022506 | ENSPPYP00000020645 | ARHGAP6 isoform 1. | SORBS3 isoform 3. | 0.516 |
| CPZ | AGMO | ENSPPYP00000016268 | ENSPPYP00000019918 | Carboxypeptidase Z isoform X1. | AGMO isoform 1; Belongs to the sterol desaturase family. | 0.569 |
