ASB4 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASB15	ASB4	ENSPPYP00000020143	ENSPPYP00000019953	Ankyrin repeat and SOCS box containing 15.	Ankyrin repeat and SOCS box containing 4.	0.662
ASB15	ASB9	ENSPPYP00000020143	ENSPPYP00000022530	Ankyrin repeat and SOCS box containing 15.	Ankyrin repeat and SOCS box containing 9.	0.406
ASB15	CR201_G0003257	ENSPPYP00000020143	ENSPPYP00000013806	Ankyrin repeat and SOCS box containing 15.	COMMD1 isoform 4.	0.499
ASB15	CUL5	ENSPPYP00000020143	ENSPPYP00000004398	Ankyrin repeat and SOCS box containing 15.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.577
ASB4	ASB15	ENSPPYP00000019953	ENSPPYP00000020143	Ankyrin repeat and SOCS box containing 4.	Ankyrin repeat and SOCS box containing 15.	0.662
ASB4	ASB9	ENSPPYP00000019953	ENSPPYP00000022530	Ankyrin repeat and SOCS box containing 4.	Ankyrin repeat and SOCS box containing 9.	0.643
ASB4	CHRAC1	ENSPPYP00000019953	ENSPPYP00000021211	Ankyrin repeat and SOCS box containing 4.	Chromatin accessibility complex subunit 1.	0.740
ASB4	CR201_G0003257	ENSPPYP00000019953	ENSPPYP00000013806	Ankyrin repeat and SOCS box containing 4.	COMMD1 isoform 4.	0.634
ASB4	CUL5	ENSPPYP00000019953	ENSPPYP00000004398	Ankyrin repeat and SOCS box containing 4.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.809
ASB4	DNAJB5	ENSPPYP00000019953	ENSPPYP00000022281	Ankyrin repeat and SOCS box containing 4.	DnaJ heat shock protein family (Hsp40) member B5.	0.735
ASB4	HERC3	ENSPPYP00000019953	ENSPPYP00000016667	Ankyrin repeat and SOCS box containing 4.	HERC3 isoform 11.	0.667
ASB4	HIF1AN	ENSPPYP00000019953	ENSPPYP00000002984	Ankyrin repeat and SOCS box containing 4.	Hypoxia inducible factor 1 subunit alpha inhibitor.	0.747
ASB4	TRAPPC9	ENSPPYP00000019953	ENSPPYP00000021208	Ankyrin repeat and SOCS box containing 4.	TRAPPC9 isoform 1.	0.674
ASB4	WDR6	ENSPPYP00000019953	ENSPPYP00000015535	Ankyrin repeat and SOCS box containing 4.	WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.	0.645
ASB9	ASB15	ENSPPYP00000022530	ENSPPYP00000020143	Ankyrin repeat and SOCS box containing 9.	Ankyrin repeat and SOCS box containing 15.	0.406
ASB9	ASB4	ENSPPYP00000022530	ENSPPYP00000019953	Ankyrin repeat and SOCS box containing 9.	Ankyrin repeat and SOCS box containing 4.	0.643
ASB9	CR201_G0003257	ENSPPYP00000022530	ENSPPYP00000013806	Ankyrin repeat and SOCS box containing 9.	COMMD1 isoform 4.	0.553
ASB9	CUL5	ENSPPYP00000022530	ENSPPYP00000004398	Ankyrin repeat and SOCS box containing 9.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.980
ASB9	HIF1AN	ENSPPYP00000022530	ENSPPYP00000002984	Ankyrin repeat and SOCS box containing 9.	Hypoxia inducible factor 1 subunit alpha inhibitor.	0.919
CHRAC1	ASB4	ENSPPYP00000021211	ENSPPYP00000019953	Chromatin accessibility complex subunit 1.	Ankyrin repeat and SOCS box containing 4.	0.740