| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH25H | CYP51A1 | ENSPPYP00000002851 | ENSPPYP00000019976 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.962 |
| CH25H | DHCR24 | ENSPPYP00000002851 | ENSPPYP00000001525 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR24 isoform 1. | 0.912 |
| CH25H | HMGCS1 | ENSPPYP00000002851 | ENSPPYP00000017251 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.880 |
| CH25H | LBR | ENSPPYP00000002851 | ENSPPYP00000000176 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Delta(14)-sterol reductase LBR; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (By similarity). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear [...] | 0.639 |
| CH25H | LSS | ENSPPYP00000002851 | ENSPPYP00000012870 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.748 |
| CH25H | NSDHL | ENSPPYP00000002851 | ENSPPYP00000023318 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | NSDHL isoform 1; Belongs to the 3-beta-HSD family. | 0.849 |
| CH25H | SC5D | ENSPPYP00000002851 | ENSPPYP00000004558 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.905 |
| CH25H | SQLE | ENSPPYP00000002851 | ENSPPYP00000021174 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | SQLE isoform 1. | 0.949 |
| CH25H | TM7SF2 | ENSPPYP00000002851 | ENSPPYP00000003564 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | TM7SF2 isoform 10. | 0.680 |
| CYP51A1 | CH25H | ENSPPYP00000019976 | ENSPPYP00000002851 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.962 |
| CYP51A1 | DHCR24 | ENSPPYP00000019976 | ENSPPYP00000001525 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | DHCR24 isoform 1. | 0.983 |
| CYP51A1 | HMGCS1 | ENSPPYP00000019976 | ENSPPYP00000017251 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.962 |
| CYP51A1 | LBR | ENSPPYP00000019976 | ENSPPYP00000000176 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Delta(14)-sterol reductase LBR; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (By similarity). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear [...] | 0.980 |
| CYP51A1 | LSS | ENSPPYP00000019976 | ENSPPYP00000012870 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.997 |
| CYP51A1 | MSMO1 | ENSPPYP00000019976 | ENSPPYP00000016960 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. | 0.979 |
| CYP51A1 | NSDHL | ENSPPYP00000019976 | ENSPPYP00000023318 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | NSDHL isoform 1; Belongs to the 3-beta-HSD family. | 0.950 |
| CYP51A1 | SC5D | ENSPPYP00000019976 | ENSPPYP00000004558 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.942 |
| CYP51A1 | SQLE | ENSPPYP00000019976 | ENSPPYP00000021174 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | SQLE isoform 1. | 0.981 |
| CYP51A1 | TM7SF2 | ENSPPYP00000019976 | ENSPPYP00000003564 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | TM7SF2 isoform 10. | 0.985 |
| DHCR24 | CH25H | ENSPPYP00000001525 | ENSPPYP00000002851 | DHCR24 isoform 1. | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.912 |
