| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | HRAS | ENSPPYP00000007036 | ENSPPYP00000003333 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | HRas proto-oncogene, GTPase. | 0.586 |
| AKT1 | IRS4 | ENSPPYP00000007036 | ENSPPYP00000023087 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Insulin receptor substrate 4. | 0.692 |
| AKT1 | KRAS | ENSPPYP00000007036 | ENSPPYP00000004987 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | KRAS proto-oncogene, GTPase. | 0.664 |
| AKT1 | LYN | ENSPPYP00000007036 | ENSPPYP00000020857 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Tyrosine-protein kinase. | 0.569 |
| AKT1 | NRAS | ENSPPYP00000007036 | ENSPPYP00000001163 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.546 |
| AKT1 | PDPK1 | ENSPPYP00000007036 | ENSPPYP00000007927 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | PDPK1 isoform 1. | 0.997 |
| AKT1 | PIK3CG | ENSPPYP00000007036 | ENSPPYP00000020059 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | PIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. | 0.988 |
| AKT1 | PIK3R1 | ENSPPYP00000007036 | ENSPPYP00000017341 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.992 |
| AKT1 | PIK3R5 | ENSPPYP00000007036 | ENSPPYP00000008960 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | PIK3R5 isoform 10. | 0.940 |
| AKT1 | PIK3R6 | ENSPPYP00000007036 | ENSPPYP00000008959 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | PIK3R6 isoform 2. | 0.918 |
| HRAS | AKT1 | ENSPPYP00000003333 | ENSPPYP00000007036 | HRas proto-oncogene, GTPase. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.586 |
| HRAS | KRAS | ENSPPYP00000003333 | ENSPPYP00000004987 | HRas proto-oncogene, GTPase. | KRAS proto-oncogene, GTPase. | 0.997 |
| HRAS | LYN | ENSPPYP00000003333 | ENSPPYP00000020857 | HRas proto-oncogene, GTPase. | Tyrosine-protein kinase. | 0.459 |
| HRAS | NRAS | ENSPPYP00000003333 | ENSPPYP00000001163 | HRas proto-oncogene, GTPase. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.997 |
| HRAS | PDPK1 | ENSPPYP00000003333 | ENSPPYP00000007927 | HRas proto-oncogene, GTPase. | PDPK1 isoform 1. | 0.408 |
| HRAS | PIK3CG | ENSPPYP00000003333 | ENSPPYP00000020059 | HRas proto-oncogene, GTPase. | PIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. | 0.987 |
| HRAS | PIK3R1 | ENSPPYP00000003333 | ENSPPYP00000017341 | HRas proto-oncogene, GTPase. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.986 |
| HRAS | PIK3R5 | ENSPPYP00000003333 | ENSPPYP00000008960 | HRas proto-oncogene, GTPase. | PIK3R5 isoform 10. | 0.905 |
| HRAS | PIK3R6 | ENSPPYP00000003333 | ENSPPYP00000008959 | HRas proto-oncogene, GTPase. | PIK3R6 isoform 2. | 0.901 |
| IRS4 | AKT1 | ENSPPYP00000023087 | ENSPPYP00000007036 | Insulin receptor substrate 4. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.692 |
