CAV1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML3	CALML4	ENSPPYP00000002383	ENSPPYP00000007472	CALML3 isoform 1; Belongs to the calmodulin family.	LOW QUALITY PROTEIN: calmodulin-like protein 4.	0.945
CALML3	CALML5	ENSPPYP00000002383	ENSPPYP00000002382	CALML3 isoform 1; Belongs to the calmodulin family.	Calmodulin like 5.	0.956
CALML3	CAV1	ENSPPYP00000002383	ENSPPYP00000020105	CALML3 isoform 1; Belongs to the calmodulin family.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.857
CALML3	CAV2	ENSPPYP00000002383	ENSPPYP00000020104	CALML3 isoform 1; Belongs to the calmodulin family.	Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...]	0.838
CALML3	CAV3	ENSPPYP00000002383	ENSPPYP00000015308	CALML3 isoform 1; Belongs to the calmodulin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.847
CALML3	EGFR	ENSPPYP00000002383	ENSPPYP00000019671	CALML3 isoform 1; Belongs to the calmodulin family.	Receptor protein-tyrosine kinase.	0.475
CALML3	NOS3	ENSPPYP00000002383	ENSPPYP00000020384	CALML3 isoform 1; Belongs to the calmodulin family.	NOS3 isoform 2.	0.974
CALML3	SRC	ENSPPYP00000002383	ENSPPYP00000012270	CALML3 isoform 1; Belongs to the calmodulin family.	Tyrosine-protein kinase.	0.406
CALML4	CALML3	ENSPPYP00000007472	ENSPPYP00000002383	LOW QUALITY PROTEIN: calmodulin-like protein 4.	CALML3 isoform 1; Belongs to the calmodulin family.	0.945
CALML4	CALML5	ENSPPYP00000007472	ENSPPYP00000002382	LOW QUALITY PROTEIN: calmodulin-like protein 4.	Calmodulin like 5.	0.951
CALML4	CAV1	ENSPPYP00000007472	ENSPPYP00000020105	LOW QUALITY PROTEIN: calmodulin-like protein 4.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.902
CALML4	CAV2	ENSPPYP00000007472	ENSPPYP00000020104	LOW QUALITY PROTEIN: calmodulin-like protein 4.	Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...]	0.914
CALML4	CAV3	ENSPPYP00000007472	ENSPPYP00000015308	LOW QUALITY PROTEIN: calmodulin-like protein 4.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.923
CALML4	NOS3	ENSPPYP00000007472	ENSPPYP00000020384	LOW QUALITY PROTEIN: calmodulin-like protein 4.	NOS3 isoform 2.	0.954
CALML5	CALML3	ENSPPYP00000002382	ENSPPYP00000002383	Calmodulin like 5.	CALML3 isoform 1; Belongs to the calmodulin family.	0.956
CALML5	CALML4	ENSPPYP00000002382	ENSPPYP00000007472	Calmodulin like 5.	LOW QUALITY PROTEIN: calmodulin-like protein 4.	0.951
CALML5	CAV1	ENSPPYP00000002382	ENSPPYP00000020105	Calmodulin like 5.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.857
CALML5	CAV2	ENSPPYP00000002382	ENSPPYP00000020104	Calmodulin like 5.	Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...]	0.837
CALML5	CAV3	ENSPPYP00000002382	ENSPPYP00000015308	Calmodulin like 5.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.846
CALML5	EGFR	ENSPPYP00000002382	ENSPPYP00000019671	Calmodulin like 5.	Receptor protein-tyrosine kinase.	0.574