MET protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	GRB2	ENSPPYP00000004540	ENSPPYP00000009686	Cbl proto-oncogene.	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	0.996
CBL	HGF	ENSPPYP00000004540	ENSPPYP00000020015	Cbl proto-oncogene.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.722
CBL	MET	ENSPPYP00000004540	ENSPPYP00000020106	Cbl proto-oncogene.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.995
CBL	PIK3CA	ENSPPYP00000004540	ENSPPYP00000023529	Cbl proto-oncogene.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.967
CBL	SRC	ENSPPYP00000004540	ENSPPYP00000012270	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.972
GAB1	GRB2	ENSPPYP00000016856	ENSPPYP00000009686	GAB1 isoform 1.	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	0.999
GAB1	HGF	ENSPPYP00000016856	ENSPPYP00000020015	GAB1 isoform 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.875
GAB1	MET	ENSPPYP00000016856	ENSPPYP00000020106	GAB1 isoform 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.990
GAB1	PIK3CA	ENSPPYP00000016856	ENSPPYP00000023529	GAB1 isoform 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.978
GAB1	SRC	ENSPPYP00000016856	ENSPPYP00000012270	GAB1 isoform 1.	Tyrosine-protein kinase.	0.674
GRB2	CBL	ENSPPYP00000009686	ENSPPYP00000004540	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Cbl proto-oncogene.	0.996
GRB2	GAB1	ENSPPYP00000009686	ENSPPYP00000016856	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	GAB1 isoform 1.	0.999
GRB2	HGF	ENSPPYP00000009686	ENSPPYP00000020015	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.592
GRB2	MET	ENSPPYP00000009686	ENSPPYP00000020106	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.996
GRB2	PIK3CA	ENSPPYP00000009686	ENSPPYP00000023529	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
GRB2	PLXNB1	ENSPPYP00000009686	ENSPPYP00000015555	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	PLXNB1 isoform 1.	0.585
GRB2	PLXNB3	ENSPPYP00000009686	ENSPPYP00000023338	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	PLXNB3 isoform 1.	0.415
GRB2	PTPN1	ENSPPYP00000009686	ENSPPYP00000012433	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Tyrosine-protein phosphatase non-receptor type.	0.830
GRB2	SRC	ENSPPYP00000009686	ENSPPYP00000012270	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Tyrosine-protein kinase.	0.982
HGF	CBL	ENSPPYP00000020015	ENSPPYP00000004540	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Cbl proto-oncogene.	0.722