| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADGRA2 | FZD4 | ENSPPYP00000020751 | ENSPPYP00000004289 | ADGRA2 isoform 2; Belongs to the G-protein coupled receptor 2 family. | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.605 |
| ADGRA2 | NDP | ENSPPYP00000020751 | ENSPPYP00000022682 | ADGRA2 isoform 2; Belongs to the G-protein coupled receptor 2 family. | Norrin cystine knot growth factor NDP. | 0.402 |
| ADGRA2 | RECK | ENSPPYP00000020751 | ENSPPYP00000021373 | ADGRA2 isoform 2; Belongs to the G-protein coupled receptor 2 family. | RECK isoform 1. | 0.614 |
| ADGRA2 | TSPAN12 | ENSPPYP00000020751 | ENSPPYP00000020123 | ADGRA2 isoform 2; Belongs to the G-protein coupled receptor 2 family. | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] | 0.662 |
| ARHGAP31 | DOCK6 | ENSPPYP00000015118 | ENSPPYP00000010736 | Rho GTPase activating protein 31. | DOCK6 isoform 2; Belongs to the DOCK family. | 0.549 |
| ARHGAP31 | JAG1 | ENSPPYP00000015118 | ENSPPYP00000011973 | Rho GTPase activating protein 31. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.618 |
| ARHGAP31 | KIF11 | ENSPPYP00000015118 | ENSPPYP00000002878 | Rho GTPase activating protein 31. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.725 |
| ARHGAP31 | RCBTB1 | ENSPPYP00000015118 | ENSPPYP00000006118 | Rho GTPase activating protein 31. | RCC1 and BTB domain containing protein 1. | 0.788 |
| ARHGAP31 | TSPAN12 | ENSPPYP00000015118 | ENSPPYP00000020123 | Rho GTPase activating protein 31. | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] | 0.749 |
| ARHGAP31 | ZNF408 | ENSPPYP00000015118 | ENSPPYP00000003809 | Rho GTPase activating protein 31. | ZNF408 isoform 1. | 0.764 |
| DOCK6 | ARHGAP31 | ENSPPYP00000010736 | ENSPPYP00000015118 | DOCK6 isoform 2; Belongs to the DOCK family. | Rho GTPase activating protein 31. | 0.549 |
| DOCK6 | JAG1 | ENSPPYP00000010736 | ENSPPYP00000011973 | DOCK6 isoform 2; Belongs to the DOCK family. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.566 |
| DOCK6 | KIF11 | ENSPPYP00000010736 | ENSPPYP00000002878 | DOCK6 isoform 2; Belongs to the DOCK family. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.782 |
| DOCK6 | RCBTB1 | ENSPPYP00000010736 | ENSPPYP00000006118 | DOCK6 isoform 2; Belongs to the DOCK family. | RCC1 and BTB domain containing protein 1. | 0.801 |
| DOCK6 | TSPAN12 | ENSPPYP00000010736 | ENSPPYP00000020123 | DOCK6 isoform 2; Belongs to the DOCK family. | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] | 0.788 |
| DOCK6 | ZNF408 | ENSPPYP00000010736 | ENSPPYP00000003809 | DOCK6 isoform 2; Belongs to the DOCK family. | ZNF408 isoform 1. | 0.791 |
| FZD4 | ADGRA2 | ENSPPYP00000004289 | ENSPPYP00000020751 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | ADGRA2 isoform 2; Belongs to the G-protein coupled receptor 2 family. | 0.605 |
| FZD4 | KIF11 | ENSPPYP00000004289 | ENSPPYP00000002878 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.541 |
| FZD4 | NDP | ENSPPYP00000004289 | ENSPPYP00000022682 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Norrin cystine knot growth factor NDP. | 0.952 |
| FZD4 | RCBTB1 | ENSPPYP00000004289 | ENSPPYP00000006118 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | RCC1 and BTB domain containing protein 1. | 0.660 |
