STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRSS58Serine protease 58; Belongs to the peptidase S1 family. (241 aa)    
Predicted Functional Partners:
DBH
DBH isoform 1.
      
 0.794
SPINK1
Serine peptidase inhibitor, Kazal type 1.
    
 0.755
MGAM
MGAM isoform 2.
      
 0.739
TAS1R3
TAS1R3 isoform 1.
    
 
 0.693
PALB2
Partner and localizer of BRCA2.
     
 0.643
STK11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
    
 
 0.554
CR201_G0045651
PRSS27 isoform 3; Belongs to the peptidase S1 family.
  
     0.522
CFTR
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]
      
 0.518
CPA1
Carboxypeptidase A1.
   
 
 0.507
MST1R
MST1R isoform 1.
    
 0.501
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.