| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF5 | ARHGEF6 | ENSPPYP00000020344 | ENSPPYP00000023253 | ARHGEF35 isoform 1. | Rac/Cdc42 guanine nucleotide exchange factor 6. | 0.757 |
| ARHGEF5 | CD8B | ENSPPYP00000020344 | ENSPPYP00000013609 | ARHGEF35 isoform 1. | CD8B isoform 1. | 0.671 |
| ARHGEF5 | CORO6 | ENSPPYP00000020344 | ENSPPYP00000009137 | ARHGEF35 isoform 1. | Coronin; Belongs to the WD repeat coronin family. | 0.658 |
| ARHGEF5 | DUSP22 | ENSPPYP00000020344 | ENSPPYP00000018076 | ARHGEF35 isoform 1. | Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.778 |
| ARHGEF5 | OPHN1 | ENSPPYP00000020344 | ENSPPYP00000022866 | ARHGEF35 isoform 1. | OPHN1 isoform 1. | 0.662 |
| ARHGEF5 | PTPN20 | ENSPPYP00000020344 | ENSPPYP00000002616 | ARHGEF35 isoform 1. | PTPN20 isoform 13. | 0.678 |
| ARHGEF5 | RHOA | ENSPPYP00000020344 | ENSPPYP00000015522 | ARHGEF35 isoform 1. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.741 |
| ARHGEF5 | ROCK1 | ENSPPYP00000020344 | ENSPPYP00000010161 | ARHGEF35 isoform 1. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.860 |
| ARHGEF5 | SRGAP2 | ENSPPYP00000020344 | ENSPPYP00000000309 | ARHGEF35 isoform 1. | SLIT-ROBO Rho GTPase activating protein 2. | 0.721 |
| ARHGEF5 | TCAF1 | ENSPPYP00000020344 | ENSPPYP00000020335 | ARHGEF35 isoform 1. | TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner; Belongs to the TCAF family. | 0.734 |
| ARHGEF6 | ARHGEF5 | ENSPPYP00000023253 | ENSPPYP00000020344 | Rac/Cdc42 guanine nucleotide exchange factor 6. | ARHGEF35 isoform 1. | 0.757 |
| ARHGEF6 | OPHN1 | ENSPPYP00000023253 | ENSPPYP00000022866 | Rac/Cdc42 guanine nucleotide exchange factor 6. | OPHN1 isoform 1. | 0.670 |
| ARHGEF6 | RHOA | ENSPPYP00000023253 | ENSPPYP00000015522 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.511 |
| ARHGEF6 | ROCK1 | ENSPPYP00000023253 | ENSPPYP00000010161 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.725 |
| ARHGEF6 | SRGAP2 | ENSPPYP00000023253 | ENSPPYP00000000309 | Rac/Cdc42 guanine nucleotide exchange factor 6. | SLIT-ROBO Rho GTPase activating protein 2. | 0.745 |
| CD8B | ARHGEF5 | ENSPPYP00000013609 | ENSPPYP00000020344 | CD8B isoform 1. | ARHGEF35 isoform 1. | 0.671 |
| CD8B | DUSP22 | ENSPPYP00000013609 | ENSPPYP00000018076 | CD8B isoform 1. | Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.721 |
| CD8B | PTPN20 | ENSPPYP00000013609 | ENSPPYP00000002616 | CD8B isoform 1. | PTPN20 isoform 13. | 0.655 |
| CD8B | ROCK1 | ENSPPYP00000013609 | ENSPPYP00000010161 | CD8B isoform 1. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.551 |
| CD8B | TCAF1 | ENSPPYP00000013609 | ENSPPYP00000020335 | CD8B isoform 1. | TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner; Belongs to the TCAF family. | 0.743 |
