STRINGSTRING
CUL1 protein (Pongo abelii) - STRING interaction network
"CUL1" - Cullin-1 in Pongo abelii
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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CUL1Cullin-1 ; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] (776 aa)    
Predicted Functional Partners:
SKP1
S-phase kinase-associated protein 1 ; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTR [...] (163 aa)
     
  0.999
RBX1
Ring-box 1, E3 ubiquitin protein ligase (108 aa)
     
  0.998
BTRC
F-box/WD repeat-containing protein 1A (605 aa)
     
  0.988
UBE2M
Ubiquitin-conjugating enzyme E2M (183 aa)
     
  0.988
NEDD8
Neural precursor cell expressed, developmentally down-regulated 8 (81 aa)
     
  0.984
FBXW7
F-box/WD repeat-containing protein 7 (627 aa)
     
  0.983
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase (410 aa)
     
  0.980
CAND1
Cullin-associated NEDD8-dissociated protein 1 ; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation- in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar [...] (1230 aa)
     
 
  0.970
CDK2
Cyclin-dependent kinase 2 (298 aa)
     
  0.964
COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (334 aa)
     
  0.950
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Ponginae, Pongo, Pongo abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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