STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DPP6DPP6 isoform 3; Belongs to the peptidase S9B family. (784 aa)    
Predicted Functional Partners:
KCND2
KCND2 isoform 1; Belongs to the potassium channel family.
    
 
 0.963
KCNIP1
Potassium voltage-gated channel interacting protein 1.
   
 
 0.897
KCND3
Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.
    
 
 0.852
KCNC1
Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family.
   
 
 0.717
IGLON5
Opioid binding protein/cell adhesion molecule-like.
   
 
 0.707
KCNIP2
KCNIP2 isoform 8.
   
 
 0.695
LGI1
Leucine-rich glioma-inactivated protein 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity).
   
  
 0.685
SCN5A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
      
 0.685
ITPR2
Inositol 1,4,5-trisphosphate receptor type 2.
      
 0.674
KCND1
KCND1 isoform 1; Belongs to the potassium channel family.
    
 
 0.629
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.