| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0040134 | LOC100437365 | ENSPPYP00000021616 | ENSPPYP00000015838 | NMRK1 isoform 1. | Nicotinamide-nucleotide adenylyltransferase. | 0.953 |
| CR201_G0040134 | NAMPT | ENSPPYP00000021616 | ENSPPYP00000020466 | NMRK1 isoform 1. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.947 |
| CR201_G0040134 | NMNAT2 | ENSPPYP00000021616 | ENSPPYP00000000486 | NMRK1 isoform 1. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.951 |
| CR201_G0040134 | SIRT1 | ENSPPYP00000021616 | ENSPPYP00000002788 | NMRK1 isoform 1. | SIRT1 isoform 1. | 0.600 |
| CR201_G0040134 | SIRT2 | ENSPPYP00000021616 | ENSPPYP00000023731 | NMRK1 isoform 1. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] | 0.578 |
| LOC100437365 | CR201_G0040134 | ENSPPYP00000015838 | ENSPPYP00000021616 | Nicotinamide-nucleotide adenylyltransferase. | NMRK1 isoform 1. | 0.953 |
| LOC100437365 | NAMPT | ENSPPYP00000015838 | ENSPPYP00000020466 | Nicotinamide-nucleotide adenylyltransferase. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.960 |
| LOC100437365 | NMNAT2 | ENSPPYP00000015838 | ENSPPYP00000000486 | Nicotinamide-nucleotide adenylyltransferase. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.941 |
| LOC100437365 | SARM1 | ENSPPYP00000015838 | ENSPPYP00000009100 | Nicotinamide-nucleotide adenylyltransferase. | Sterile alpha and TIR motif containing 1. | 0.973 |
| LOC100437365 | SIRT1 | ENSPPYP00000015838 | ENSPPYP00000002788 | Nicotinamide-nucleotide adenylyltransferase. | SIRT1 isoform 1. | 0.940 |
| LOC100437365 | SIRT2 | ENSPPYP00000015838 | ENSPPYP00000023731 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] | 0.913 |
| LOC100437365 | SIRT3 | ENSPPYP00000015838 | ENSPPYP00000022355 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.926 |
| LOC100437365 | SIRT4 | ENSPPYP00000015838 | ENSPPYP00000005727 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.926 |
| LOC100437365 | SIRT6 | ENSPPYP00000015838 | ENSPPYP00000010537 | Nicotinamide-nucleotide adenylyltransferase. | SIRT6 isoform 1. | 0.925 |
| NAMPT | CR201_G0040134 | ENSPPYP00000020466 | ENSPPYP00000021616 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NMRK1 isoform 1. | 0.947 |
| NAMPT | LOC100437365 | ENSPPYP00000020466 | ENSPPYP00000015838 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Nicotinamide-nucleotide adenylyltransferase. | 0.960 |
| NAMPT | NMNAT2 | ENSPPYP00000020466 | ENSPPYP00000000486 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.959 |
| NAMPT | NNMT | ENSPPYP00000020466 | ENSPPYP00000004459 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Nicotinamide N-methyltransferase. | 0.935 |
| NAMPT | SARM1 | ENSPPYP00000020466 | ENSPPYP00000009100 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sterile alpha and TIR motif containing 1. | 0.934 |
| NAMPT | SIRT1 | ENSPPYP00000020466 | ENSPPYP00000002788 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | SIRT1 isoform 1. | 0.961 |
