| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG16L1 | DEFA6 | ENSPPYP00000014856 | ENSPPYP00000020532 | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] | Defensin alpha 6. | 0.667 |
| ATG16L1 | ITLN2 | ENSPPYP00000014856 | ENSPPYP00000000724 | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] | ITLN2 isoform 1. | 0.781 |
| ATG16L1 | LYZ | ENSPPYP00000014856 | ENSPPYP00000005419 | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | 0.772 |
| CR201_G0035435 | DEFA4 | ENSPPYP00000021313 | ENSPPYP00000020533 | DEFA5 isoform 1. | Neutrophil defensin 4. | 0.949 |
| CR201_G0035435 | DEFA6 | ENSPPYP00000021313 | ENSPPYP00000020532 | DEFA5 isoform 1. | Defensin alpha 6. | 0.995 |
| CR201_G0035435 | ITLN2 | ENSPPYP00000021313 | ENSPPYP00000000724 | DEFA5 isoform 1. | ITLN2 isoform 1. | 0.699 |
| CR201_G0035435 | LOC100435661 | ENSPPYP00000021313 | ENSPPYP00000020550 | DEFA5 isoform 1. | DEFB103B isoform 1. | 0.953 |
| CR201_G0035435 | LOC100436028 | ENSPPYP00000021313 | ENSPPYP00000020552 | DEFA5 isoform 1. | DEFB4A isoform 1. | 0.954 |
| CR201_G0035435 | LOC112131868 | ENSPPYP00000021313 | ENSPPYP00000021326 | DEFA5 isoform 1. | DEFA1 isoform 1. | 0.915 |
| CR201_G0035435 | LYZ | ENSPPYP00000021313 | ENSPPYP00000005419 | DEFA5 isoform 1. | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | 0.725 |
| CR201_G0035435 | REG3A | ENSPPYP00000021313 | ENSPPYP00000013659 | DEFA5 isoform 1. | Regenerating family member 3 alpha. | 0.875 |
| DEFA4 | CR201_G0035435 | ENSPPYP00000020533 | ENSPPYP00000021313 | Neutrophil defensin 4. | DEFA5 isoform 1. | 0.949 |
| DEFA4 | DEFA6 | ENSPPYP00000020533 | ENSPPYP00000020532 | Neutrophil defensin 4. | Defensin alpha 6. | 0.930 |
| DEFA4 | LOC100435661 | ENSPPYP00000020533 | ENSPPYP00000020550 | Neutrophil defensin 4. | DEFB103B isoform 1. | 0.927 |
| DEFA4 | LOC100436028 | ENSPPYP00000020533 | ENSPPYP00000020552 | Neutrophil defensin 4. | DEFB4A isoform 1. | 0.947 |
| DEFA4 | LOC112131868 | ENSPPYP00000020533 | ENSPPYP00000021326 | Neutrophil defensin 4. | DEFA1 isoform 1. | 0.935 |
| DEFA4 | ZFPM1 | ENSPPYP00000020533 | ENSPPYP00000008615 | Neutrophil defensin 4. | ZFPM1 isoform 1. | 0.593 |
| DEFA6 | ATG16L1 | ENSPPYP00000020532 | ENSPPYP00000014856 | Defensin alpha 6. | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] | 0.667 |
| DEFA6 | CR201_G0035435 | ENSPPYP00000020532 | ENSPPYP00000021313 | Defensin alpha 6. | DEFA5 isoform 1. | 0.995 |
| DEFA6 | DEFA4 | ENSPPYP00000020532 | ENSPPYP00000020533 | Defensin alpha 6. | Neutrophil defensin 4. | 0.930 |
