STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. (339 aa)    
Predicted Functional Partners:
CSTA
CSTA isoform 1; Belongs to the cystatin family.
   
 0.978
CD74
CD74 isoform 2.
   
 0.960
BCL2
BCL2 isoform 1.
   
 
 0.931
NLRP3
NLRP3 isoform 2.
   
 
 0.928
BCL2L1
BCL2L1 isoform 2.
     
 0.920
BID-2
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 
 0.906
GABPB1
GABPB1 isoform 1.
    
   0.876
IFITM10
IFITM10 isoform 1.
   
 0.863
CST3
CST3 isoform 1; Belongs to the cystatin family.
   
 0.842
ANXA2
Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.
   
 0.816
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: medium (48%) [HD]