BLK protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BANK1	BLK	ENSPPYP00000016709	ENSPPYP00000020565	BANK1 isoform 3.	Tyrosine-protein kinase.	0.978
BANK1	PLCG2	ENSPPYP00000016709	ENSPPYP00000008564	BANK1 isoform 3.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.916
BLK	BANK1	ENSPPYP00000020565	ENSPPYP00000016709	Tyrosine-protein kinase.	BANK1 isoform 3.	0.978
BLK	CDK20	ENSPPYP00000020565	ENSPPYP00000021685	Tyrosine-protein kinase.	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	0.929
BLK	CR201_G0040881	ENSPPYP00000020565	ENSPPYP00000016240	Tyrosine-protein kinase.	Fibroblast growth factor receptor.	0.946
BLK	FGFR1	ENSPPYP00000020565	ENSPPYP00000020767	Tyrosine-protein kinase.	Fibroblast growth factor receptor.	0.915
BLK	FGFR2	ENSPPYP00000020565	ENSPPYP00000003165	Tyrosine-protein kinase.	Fibroblast growth factor receptor.	0.947
BLK	FGFR4	ENSPPYP00000020565	ENSPPYP00000017999	Tyrosine-protein kinase.	Fibroblast growth factor receptor.	0.947
BLK	FGR	ENSPPYP00000020565	ENSPPYP00000001917	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.908
BLK	ICK	ENSPPYP00000020565	ENSPPYP00000018700	Tyrosine-protein kinase.	Intestinal cell kinase.	0.929
BLK	MAK	ENSPPYP00000020565	ENSPPYP00000018149	Tyrosine-protein kinase.	MAK isoform 1.	0.929
BLK	PLCG2	ENSPPYP00000020565	ENSPPYP00000008564	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.949
CDK20	BLK	ENSPPYP00000021685	ENSPPYP00000020565	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Tyrosine-protein kinase.	0.929
CDK20	CR201_G0040881	ENSPPYP00000021685	ENSPPYP00000016240	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Fibroblast growth factor receptor.	0.932
CDK20	FGFR1	ENSPPYP00000021685	ENSPPYP00000020767	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Fibroblast growth factor receptor.	0.930
CDK20	FGFR2	ENSPPYP00000021685	ENSPPYP00000003165	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Fibroblast growth factor receptor.	0.932
CDK20	FGFR4	ENSPPYP00000021685	ENSPPYP00000017999	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Fibroblast growth factor receptor.	0.932
CDK20	FGR	ENSPPYP00000021685	ENSPPYP00000001917	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Tyrosine-protein kinase.	0.847
CDK20	ICK	ENSPPYP00000021685	ENSPPYP00000018700	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	Intestinal cell kinase.	0.945
CDK20	MAK	ENSPPYP00000021685	ENSPPYP00000018149	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).	MAK isoform 1.	0.940