TNFRSF10C protein (Pongo abelii) - STRING interaction network

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TNFRSF10C

Tumor necrosis factor receptor superfamily member 10C. (167 aa)

Predicted Functional Partners:

TNFRSF10D

0.957

TNFSF10

0.845

TNFRSF10B

0.766

TNFRSF10A

0.673

CFLAR

0.560

TNF

0.482

CASP8

0.457

XIAP

0.457

DCXR

0.437

FADD

0.436

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	CFLAR	ENSPPYP00000014605	ENSPPYP00000014600	CASP8 isoform 1; Belongs to the peptidase C14A family.	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	0.999
CASP8	FADD	ENSPPYP00000014605	ENSPPYP00000003427	CASP8 isoform 1; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	TNF	ENSPPYP00000014605	ENSPPYP00000018379	CASP8 isoform 1; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family.	0.996
CASP8	TNFRSF10A	ENSPPYP00000014605	ENSPPYP00000020658	CASP8 isoform 1; Belongs to the peptidase C14A family.	TNFRSF10A isoform 1.	0.972
CASP8	TNFRSF10B	ENSPPYP00000014605	ENSPPYP00000020655	CASP8 isoform 1; Belongs to the peptidase C14A family.	TNFRSF10B isoform 3.	0.984
CASP8	TNFRSF10C	ENSPPYP00000014605	ENSPPYP00000020656	CASP8 isoform 1; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10C.	0.457
CASP8	TNFRSF10D	ENSPPYP00000014605	ENSPPYP00000020657	CASP8 isoform 1; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.671
CASP8	TNFSF10	ENSPPYP00000014605	ENSPPYP00000015988	CASP8 isoform 1; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member.	0.974
CASP8	XIAP	ENSPPYP00000014605	ENSPPYP00000023167	CASP8 isoform 1; Belongs to the peptidase C14A family.	XIAP isoform 2.	0.841
CFLAR	CASP8	ENSPPYP00000014600	ENSPPYP00000014605	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	CASP8 isoform 1; Belongs to the peptidase C14A family.	0.999
CFLAR	FADD	ENSPPYP00000014600	ENSPPYP00000003427	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CFLAR	TNF	ENSPPYP00000014600	ENSPPYP00000018379	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family.	0.653
CFLAR	TNFRSF10A	ENSPPYP00000014600	ENSPPYP00000020658	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	TNFRSF10A isoform 1.	0.964
CFLAR	TNFRSF10B	ENSPPYP00000014600	ENSPPYP00000020655	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	TNFRSF10B isoform 3.	0.937
CFLAR	TNFRSF10C	ENSPPYP00000014600	ENSPPYP00000020656	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	Tumor necrosis factor receptor superfamily member 10C.	0.560
CFLAR	TNFRSF10D	ENSPPYP00000014600	ENSPPYP00000020657	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	Uncharacterized protein.	0.642
CFLAR	TNFSF10	ENSPPYP00000014600	ENSPPYP00000015988	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	Tumor necrosis factor ligand superfamily member.	0.950
CFLAR	XIAP	ENSPPYP00000014600	ENSPPYP00000023167	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	XIAP isoform 2.	0.759
DCXR	TNFRSF10A	ENSPPYP00000009838	ENSPPYP00000020658	DCXR isoform 2.	TNFRSF10A isoform 1.	0.418
DCXR	TNFRSF10B	ENSPPYP00000009838	ENSPPYP00000020655	DCXR isoform 2.	TNFRSF10B isoform 3.	0.420