| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMPD2 | ATIC | ENSPPYP00000001238 | ENSPPYP00000014690 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.937 |
| AMPD2 | ENTPD4 | ENSPPYP00000001238 | ENSPPYP00000020661 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | 0.924 |
| AMPD2 | ENTPD6 | ENSPPYP00000001238 | ENSPPYP00000012047 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | ENTPD6 isoform 6; Belongs to the GDA1/CD39 NTPase family. | 0.921 |
| AMPD2 | GMPS | ENSPPYP00000001238 | ENSPPYP00000015909 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | GMP synthase [glutamine-hydrolyzing]. | 0.424 |
| AMPD2 | ITPA | ENSPPYP00000001238 | ENSPPYP00000012088 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.926 |
| ATIC | AMPD2 | ENSPPYP00000014690 | ENSPPYP00000001238 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.937 |
| ATIC | ENTPD4 | ENSPPYP00000014690 | ENSPPYP00000020661 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | 0.921 |
| ATIC | ENTPD6 | ENSPPYP00000014690 | ENSPPYP00000012047 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | ENTPD6 isoform 6; Belongs to the GDA1/CD39 NTPase family. | 0.912 |
| ATIC | GMPS | ENSPPYP00000014690 | ENSPPYP00000015909 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | GMP synthase [glutamine-hydrolyzing]. | 0.854 |
| ATIC | ITPA | ENSPPYP00000014690 | ENSPPYP00000012088 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.942 |
| ENTPD4 | AMPD2 | ENSPPYP00000020661 | ENSPPYP00000001238 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.924 |
| ENTPD4 | ATIC | ENSPPYP00000020661 | ENSPPYP00000014690 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.921 |
| ENTPD4 | ENTPD6 | ENSPPYP00000020661 | ENSPPYP00000012047 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | ENTPD6 isoform 6; Belongs to the GDA1/CD39 NTPase family. | 0.949 |
| ENTPD4 | GMPS | ENSPPYP00000020661 | ENSPPYP00000015909 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | GMP synthase [glutamine-hydrolyzing]. | 0.917 |
| ENTPD4 | ITPA | ENSPPYP00000020661 | ENSPPYP00000012088 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.921 |
| ENTPD4 | NME6 | ENSPPYP00000020661 | ENSPPYP00000015557 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Nucleoside diphosphate kinase. | 0.933 |
| ENTPD4 | RRM1 | ENSPPYP00000020661 | ENSPPYP00000004146 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.924 |
| ENTPD4 | RRM2 | ENSPPYP00000020661 | ENSPPYP00000014130 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Ribonucleotide reductase regulatory subunit M2. | 0.917 |
| ENTPD4 | RRM2B | ENSPPYP00000020661 | ENSPPYP00000021083 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity). Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.917 |
| ENTPD4 | UCKL1 | ENSPPYP00000020661 | ENSPPYP00000012572 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.924 |
