| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMH | CR201_G0028793 | ENSPPYP00000010485 | ENSPPYP00000007772 | AMH isoform 1. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.586 |
| AMH | CYP17A1 | ENSPPYP00000010485 | ENSPPYP00000003038 | AMH isoform 1. | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.768 |
| AMH | LHCGR | ENSPPYP00000010485 | ENSPPYP00000013861 | AMH isoform 1. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.737 |
| AMH | NR5A1 | ENSPPYP00000010485 | ENSPPYP00000021960 | AMH isoform 1. | NR5A1 isoform 2. | 0.876 |
| AMH | STAR | ENSPPYP00000010485 | ENSPPYP00000020760 | AMH isoform 1. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.748 |
| CR201_G0028793 | AMH | ENSPPYP00000007772 | ENSPPYP00000010485 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | AMH isoform 1. | 0.586 |
| CR201_G0028793 | CYP17A1 | ENSPPYP00000007772 | ENSPPYP00000003038 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.950 |
| CR201_G0028793 | FDX1 | ENSPPYP00000007772 | ENSPPYP00000004413 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | FDX1 isoform 1. | 0.934 |
| CR201_G0028793 | HSD3B1 | ENSPPYP00000007772 | ENSPPYP00000001124 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.977 |
| CR201_G0028793 | LHCGR | ENSPPYP00000007772 | ENSPPYP00000013861 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.607 |
| CR201_G0028793 | NR5A1 | ENSPPYP00000007772 | ENSPPYP00000021960 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | NR5A1 isoform 2. | 0.719 |
| CR201_G0028793 | STAR | ENSPPYP00000007772 | ENSPPYP00000020760 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.822 |
| CR201_G0028793 | STARD3 | ENSPPYP00000007772 | ENSPPYP00000009531 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | STARD3 isoform 16. | 0.534 |
| CYP17A1 | AMH | ENSPPYP00000003038 | ENSPPYP00000010485 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | AMH isoform 1. | 0.768 |
| CYP17A1 | CR201_G0028793 | ENSPPYP00000003038 | ENSPPYP00000007772 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.950 |
| CYP17A1 | FDX1 | ENSPPYP00000003038 | ENSPPYP00000004413 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | FDX1 isoform 1. | 0.504 |
| CYP17A1 | HSD3B1 | ENSPPYP00000003038 | ENSPPYP00000001124 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.979 |
| CYP17A1 | LHCGR | ENSPPYP00000003038 | ENSPPYP00000013861 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.806 |
| CYP17A1 | NR5A1 | ENSPPYP00000003038 | ENSPPYP00000021960 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | NR5A1 isoform 2. | 0.692 |
| CYP17A1 | STAR | ENSPPYP00000003038 | ENSPPYP00000020760 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.818 |
