| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HLTF | PCNA | ENSPPYP00000015873 | ENSPPYP00000012059 | HLTF isoform 1. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.977 |
| HLTF | RAD18 | ENSPPYP00000015873 | ENSPPYP00000015305 | HLTF isoform 1. | RAD18 isoform 2. | 0.936 |
| HLTF | REV3L | ENSPPYP00000015873 | ENSPPYP00000018949 | HLTF isoform 1. | REV3L isoform 3. | 0.722 |
| HLTF | UBC | ENSPPYP00000015873 | ENSPPYP00000005811 | HLTF isoform 1. | UBC isoform 2. | 0.616 |
| HLTF | UBE2N | ENSPPYP00000015873 | ENSPPYP00000005510 | HLTF isoform 1. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.881 |
| HLTF | UBE2NL | ENSPPYP00000015873 | ENSPPYP00000023275 | HLTF isoform 1. | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). | 0.881 |
| HLTF | UBE2V2 | ENSPPYP00000015873 | ENSPPYP00000020831 | HLTF isoform 1. | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] | 0.917 |
| PCNA | HLTF | ENSPPYP00000012059 | ENSPPYP00000015873 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | HLTF isoform 1. | 0.977 |
| PCNA | RAD18 | ENSPPYP00000012059 | ENSPPYP00000015305 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | RAD18 isoform 2. | 0.988 |
| PCNA | REV3L | ENSPPYP00000012059 | ENSPPYP00000018949 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | REV3L isoform 3. | 0.947 |
| PCNA | TRIP13 | ENSPPYP00000012059 | ENSPPYP00000017102 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | TRIP13 isoform 1; Belongs to the AAA ATPase family. | 0.473 |
| PCNA | UBA52 | ENSPPYP00000012059 | ENSPPYP00000010917 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | UBA52 isoform 10. | 0.869 |
| PCNA | UBC | ENSPPYP00000012059 | ENSPPYP00000005811 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | UBC isoform 2. | 0.919 |
| PCNA | UBE2N | ENSPPYP00000012059 | ENSPPYP00000005510 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.848 |
| PCNA | UBE2NL | ENSPPYP00000012059 | ENSPPYP00000023275 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). | 0.848 |
| PCNA | UBE2V2 | ENSPPYP00000012059 | ENSPPYP00000020831 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] | 0.946 |
| RAD18 | HLTF | ENSPPYP00000015305 | ENSPPYP00000015873 | RAD18 isoform 2. | HLTF isoform 1. | 0.936 |
| RAD18 | PCNA | ENSPPYP00000015305 | ENSPPYP00000012059 | RAD18 isoform 2. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.988 |
| RAD18 | REV3L | ENSPPYP00000015305 | ENSPPYP00000018949 | RAD18 isoform 2. | REV3L isoform 3. | 0.925 |
| RAD18 | RNF168 | ENSPPYP00000015305 | ENSPPYP00000016150 | RAD18 isoform 2. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.490 |
