GGH protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHFR	DHFR2	ENSPPYP00000017438	ENSPPYP00000015237	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	0.901
DHFR	FPGS	ENSPPYP00000017438	ENSPPYP00000022000	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.975
DHFR	GCSH	ENSPPYP00000017438	ENSPPYP00000008560	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.675
DHFR	GGH	ENSPPYP00000017438	ENSPPYP00000020888	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Folate gamma-glutamyl hydrolase.	0.921
DHFR2	DHFR	ENSPPYP00000015237	ENSPPYP00000017438	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	0.901
DHFR2	FPGS	ENSPPYP00000015237	ENSPPYP00000022000	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.975
DHFR2	GCSH	ENSPPYP00000015237	ENSPPYP00000008560	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.675
DHFR2	GGH	ENSPPYP00000015237	ENSPPYP00000020888	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	Folate gamma-glutamyl hydrolase.	0.921
FPGS	DHFR	ENSPPYP00000022000	ENSPPYP00000017438	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	0.975
FPGS	DHFR2	ENSPPYP00000022000	ENSPPYP00000015237	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	0.975
FPGS	GCSH	ENSPPYP00000022000	ENSPPYP00000008560	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.519
FPGS	GGH	ENSPPYP00000022000	ENSPPYP00000020888	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Folate gamma-glutamyl hydrolase.	0.946
FPGS	SLC19A1	ENSPPYP00000022000	ENSPPYP00000012863	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	SLC19A1 isoform 5.	0.456
GCSH	DHFR	ENSPPYP00000008560	ENSPPYP00000017438	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	0.675
GCSH	DHFR2	ENSPPYP00000008560	ENSPPYP00000015237	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	0.675
GCSH	FPGS	ENSPPYP00000008560	ENSPPYP00000022000	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.519
GCSH	GGH	ENSPPYP00000008560	ENSPPYP00000020888	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Folate gamma-glutamyl hydrolase.	0.823
GGH	DHFR	ENSPPYP00000020888	ENSPPYP00000017438	Folate gamma-glutamyl hydrolase.	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	0.921
GGH	DHFR2	ENSPPYP00000020888	ENSPPYP00000015237	Folate gamma-glutamyl hydrolase.	Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family.	0.921
GGH	FPGS	ENSPPYP00000020888	ENSPPYP00000022000	Folate gamma-glutamyl hydrolase.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.946