| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDK1 | UBC | ENSPPYP00000002808 | ENSPPYP00000005811 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | UBC isoform 2. | 0.517 |
| CDK1 | VCPIP1 | ENSPPYP00000002808 | ENSPPYP00000020915 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | VCPIP1 isoform 1. | 0.907 |
| FAF2 | NPLOC4 | ENSPPYP00000017988 | ENSPPYP00000024006 | Fas associated factor family member 2. | NPLOC4 isoform 1. | 0.969 |
| FAF2 | NSFL1C | ENSPPYP00000017988 | ENSPPYP00000012121 | Fas associated factor family member 2. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | 0.510 |
| FAF2 | UBC | ENSPPYP00000017988 | ENSPPYP00000005811 | Fas associated factor family member 2. | UBC isoform 2. | 0.500 |
| FAF2 | UBXN2A | ENSPPYP00000017988 | ENSPPYP00000014077 | Fas associated factor family member 2. | UBXN2A isoform 2. | 0.546 |
| FAF2 | UBXN2B | ENSPPYP00000017988 | ENSPPYP00000020868 | Fas associated factor family member 2. | UBX domain protein 2B. | 0.522 |
| FAF2 | UBXN7 | ENSPPYP00000017988 | ENSPPYP00000016149 | Fas associated factor family member 2. | UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity). | 0.964 |
| FAF2 | UFD1 | ENSPPYP00000017988 | ENSPPYP00000012917 | Fas associated factor family member 2. | Ubiquitin recognition factor in ER associated degradation 1. | 0.969 |
| FAF2 | VCP | ENSPPYP00000017988 | ENSPPYP00000021408 | Fas associated factor family member 2. | Transitional endoplasmic reticulum ATPase isoform X1. | 0.983 |
| FAF2 | VCPIP1 | ENSPPYP00000017988 | ENSPPYP00000020915 | Fas associated factor family member 2. | VCPIP1 isoform 1. | 0.797 |
| NPLOC4 | FAF2 | ENSPPYP00000024006 | ENSPPYP00000017988 | NPLOC4 isoform 1. | Fas associated factor family member 2. | 0.969 |
| NPLOC4 | NSFL1C | ENSPPYP00000024006 | ENSPPYP00000012121 | NPLOC4 isoform 1. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | 0.962 |
| NPLOC4 | UBC | ENSPPYP00000024006 | ENSPPYP00000005811 | NPLOC4 isoform 1. | UBC isoform 2. | 0.912 |
| NPLOC4 | UBXN2A | ENSPPYP00000024006 | ENSPPYP00000014077 | NPLOC4 isoform 1. | UBXN2A isoform 2. | 0.625 |
| NPLOC4 | UBXN2B | ENSPPYP00000024006 | ENSPPYP00000020868 | NPLOC4 isoform 1. | UBX domain protein 2B. | 0.643 |
| NPLOC4 | UBXN7 | ENSPPYP00000024006 | ENSPPYP00000016149 | NPLOC4 isoform 1. | UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity). | 0.993 |
| NPLOC4 | UFD1 | ENSPPYP00000024006 | ENSPPYP00000012917 | NPLOC4 isoform 1. | Ubiquitin recognition factor in ER associated degradation 1. | 0.999 |
| NPLOC4 | VCP | ENSPPYP00000024006 | ENSPPYP00000021408 | NPLOC4 isoform 1. | Transitional endoplasmic reticulum ATPase isoform X1. | 0.998 |
| NPLOC4 | VCPIP1 | ENSPPYP00000024006 | ENSPPYP00000020915 | NPLOC4 isoform 1. | VCPIP1 isoform 1. | 0.953 |
