| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD14 | CD180 | ENSPPYP00000017732 | ENSPPYP00000017340 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | CD180 isoform 1. | 0.719 |
| CD14 | LY96 | ENSPPYP00000017732 | ENSPPYP00000020954 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lymphocyte antigen 96. | 0.964 |
| CD14 | PLCG2 | ENSPPYP00000017732 | ENSPPYP00000008564 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.732 |
| CD14 | TLR1 | ENSPPYP00000017732 | ENSPPYP00000016387 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.490 |
| CD14 | TLR2 | ENSPPYP00000017732 | ENSPPYP00000016910 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.977 |
| CD14 | TLR4 | ENSPPYP00000017732 | ENSPPYP00000021908 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.973 |
| CD180 | CD14 | ENSPPYP00000017340 | ENSPPYP00000017732 | CD180 isoform 1. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.719 |
| CD180 | LY86 | ENSPPYP00000017340 | ENSPPYP00000018121 | CD180 isoform 1. | LY86 isoform 1. | 0.997 |
| CD180 | LY96 | ENSPPYP00000017340 | ENSPPYP00000020954 | CD180 isoform 1. | Lymphocyte antigen 96. | 0.896 |
| CD180 | TICAM1 | ENSPPYP00000017340 | ENSPPYP00000010561 | CD180 isoform 1. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.410 |
| CD180 | TIRAP | ENSPPYP00000017340 | ENSPPYP00000004627 | CD180 isoform 1. | TIR domain containing adaptor protein. | 0.403 |
| CD180 | TLR4 | ENSPPYP00000017340 | ENSPPYP00000021908 | CD180 isoform 1. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.757 |
| LY86 | CD180 | ENSPPYP00000018121 | ENSPPYP00000017340 | LY86 isoform 1. | CD180 isoform 1. | 0.997 |
| LY86 | LY96 | ENSPPYP00000018121 | ENSPPYP00000020954 | LY86 isoform 1. | Lymphocyte antigen 96. | 0.834 |
| LY86 | TLR1 | ENSPPYP00000018121 | ENSPPYP00000016387 | LY86 isoform 1. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.581 |
| LY86 | TLR2 | ENSPPYP00000018121 | ENSPPYP00000016910 | LY86 isoform 1. | Toll-like receptor. | 0.573 |
| LY86 | TLR4 | ENSPPYP00000018121 | ENSPPYP00000021908 | LY86 isoform 1. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.638 |
| LY96 | CD14 | ENSPPYP00000020954 | ENSPPYP00000017732 | Lymphocyte antigen 96. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.964 |
| LY96 | CD180 | ENSPPYP00000020954 | ENSPPYP00000017340 | Lymphocyte antigen 96. | CD180 isoform 1. | 0.896 |
| LY96 | LY86 | ENSPPYP00000020954 | ENSPPYP00000018121 | Lymphocyte antigen 96. | LY86 isoform 1. | 0.834 |
