| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP1B3 | CFTR | ENSPPYP00000015848 | ENSPPYP00000020117 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.414 |
| ATP1B3 | SLC26A7 | ENSPPYP00000015848 | ENSPPYP00000021021 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.488 |
| CFTR | ATP1B3 | ENSPPYP00000020117 | ENSPPYP00000015848 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. | 0.414 |
| CFTR | SLC26A7 | ENSPPYP00000020117 | ENSPPYP00000021021 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.445 |
| CFTR | SLC4A2 | ENSPPYP00000020117 | ENSPPYP00000020391 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution. | 0.433 |
| CR201_G0024440 | SLC26A7 | ENSPPYP00000013032 | ENSPPYP00000021021 | RHBDD3 isoform 1. | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.528 |
| HOXD1 | SLC26A7 | ENSPPYP00000014479 | ENSPPYP00000021021 | HOXD1 isoform 1. | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.473 |
| IYD | SLC26A7 | ENSPPYP00000019149 | ENSPPYP00000021021 | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.512 |
| IYD | SLC5A5 | ENSPPYP00000019149 | ENSPPYP00000010898 | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. | Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.654 |
| SLC13A2 | SLC26A7 | ENSPPYP00000009102 | ENSPPYP00000021021 | SLC13A2 isoform 2. | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.523 |
| SLC13A2 | SLC5A5 | ENSPPYP00000009102 | ENSPPYP00000010898 | SLC13A2 isoform 2. | Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.409 |
| SLC26A7 | ATP1B3 | ENSPPYP00000021021 | ENSPPYP00000015848 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. | 0.488 |
| SLC26A7 | CFTR | ENSPPYP00000021021 | ENSPPYP00000020117 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.445 |
| SLC26A7 | CR201_G0024440 | ENSPPYP00000021021 | ENSPPYP00000013032 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | RHBDD3 isoform 1. | 0.528 |
| SLC26A7 | HOXD1 | ENSPPYP00000021021 | ENSPPYP00000014479 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | HOXD1 isoform 1. | 0.473 |
| SLC26A7 | IYD | ENSPPYP00000021021 | ENSPPYP00000019149 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. | 0.512 |
| SLC26A7 | SLC13A2 | ENSPPYP00000021021 | ENSPPYP00000009102 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | SLC13A2 isoform 2. | 0.523 |
| SLC26A7 | SLC4A1 | ENSPPYP00000021021 | ENSPPYP00000009373 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Anion exchange protein. | 0.508 |
| SLC26A7 | SLC4A2 | ENSPPYP00000021021 | ENSPPYP00000020391 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution. | 0.934 |
| SLC26A7 | SLC4A9 | ENSPPYP00000021021 | ENSPPYP00000017725 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Anion exchange protein. | 0.450 |
