STK3 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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Experiments

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[Homology]

Score

STK3

STK3 isoform 3. (491 aa)

Predicted Functional Partners:

MOB1A

0.996

SAV1

0.993

LATS1

0.992

RASSF1

0.991

RASSF2

0.989

STK4

0.986

RASSF4

0.978

MOB1B

0.973

LATS2

0.972

CASP3

0.966

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	SAV1	ENSPPYP00000017020	ENSPPYP00000006597	CASP3 isoform 1; Belongs to the peptidase C14A family.	Salvador family WW domain containing protein 1.	0.656
CASP3	STK3	ENSPPYP00000017020	ENSPPYP00000021064	CASP3 isoform 1; Belongs to the peptidase C14A family.	STK3 isoform 3.	0.966
CASP3	STK4	ENSPPYP00000017020	ENSPPYP00000012335	CASP3 isoform 1; Belongs to the peptidase C14A family.	STK4 isoform 1.	0.968
LATS1	LATS2	ENSPPYP00000019136	ENSPPYP00000005920	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.991
LATS1	MOB1A	ENSPPYP00000019136	ENSPPYP00000013698	Large tumor suppressor kinase 1.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.991
LATS1	MOB1B	ENSPPYP00000019136	ENSPPYP00000016542	Large tumor suppressor kinase 1.	MOB kinase activator 1B.	0.992
LATS1	RASSF1	ENSPPYP00000019136	ENSPPYP00000015490	Large tumor suppressor kinase 1.	RASSF1 isoform 4.	0.615
LATS1	SAV1	ENSPPYP00000019136	ENSPPYP00000006597	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.975
LATS1	STK3	ENSPPYP00000019136	ENSPPYP00000021064	Large tumor suppressor kinase 1.	STK3 isoform 3.	0.992
LATS1	STK4	ENSPPYP00000019136	ENSPPYP00000012335	Large tumor suppressor kinase 1.	STK4 isoform 1.	0.825
LATS2	LATS1	ENSPPYP00000005920	ENSPPYP00000019136	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.991
LATS2	MOB1A	ENSPPYP00000005920	ENSPPYP00000013698	Non-specific serine/threonine protein kinase.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.980
LATS2	MOB1B	ENSPPYP00000005920	ENSPPYP00000016542	Non-specific serine/threonine protein kinase.	MOB kinase activator 1B.	0.981
LATS2	RASSF1	ENSPPYP00000005920	ENSPPYP00000015490	Non-specific serine/threonine protein kinase.	RASSF1 isoform 4.	0.407
LATS2	SAV1	ENSPPYP00000005920	ENSPPYP00000006597	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.976
LATS2	STK3	ENSPPYP00000005920	ENSPPYP00000021064	Non-specific serine/threonine protein kinase.	STK3 isoform 3.	0.972
LATS2	STK4	ENSPPYP00000005920	ENSPPYP00000012335	Non-specific serine/threonine protein kinase.	STK4 isoform 1.	0.898
MOB1A	LATS1	ENSPPYP00000013698	ENSPPYP00000019136	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Large tumor suppressor kinase 1.	0.991
MOB1A	LATS2	ENSPPYP00000013698	ENSPPYP00000005920	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Non-specific serine/threonine protein kinase.	0.980
MOB1A	MOB1B	ENSPPYP00000013698	ENSPPYP00000016542	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	MOB kinase activator 1B.	0.994