| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK3 | AK9 | ENSPPYP00000021553 | ENSPPYP00000018934 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | AK9 isoform 2. | 0.936 |
| AK3 | CMPK1 | ENSPPYP00000021553 | ENSPPYP00000001599 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.490 |
| AK3 | GUK1 | ENSPPYP00000021553 | ENSPPYP00000000143 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | GUK1 isoform 3. | 0.551 |
| AK3 | NME2 | ENSPPYP00000021553 | ENSPPYP00000005726 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.940 |
| AK3 | NME3 | ENSPPYP00000021553 | ENSPPYP00000007881 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.941 |
| AK3 | NME4 | ENSPPYP00000021553 | ENSPPYP00000007822 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.961 |
| AK3 | NME6 | ENSPPYP00000021553 | ENSPPYP00000015557 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.931 |
| AK3 | RRM1 | ENSPPYP00000021553 | ENSPPYP00000004146 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.957 |
| AK3 | RRM2 | ENSPPYP00000021553 | ENSPPYP00000014130 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Ribonucleotide reductase regulatory subunit M2. | 0.942 |
| AK3 | RRM2B | ENSPPYP00000021553 | ENSPPYP00000021083 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity). Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.943 |
| AK9 | AK3 | ENSPPYP00000018934 | ENSPPYP00000021553 | AK9 isoform 2. | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 0.936 |
| AK9 | CMPK1 | ENSPPYP00000018934 | ENSPPYP00000001599 | AK9 isoform 2. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.939 |
| AK9 | GUK1 | ENSPPYP00000018934 | ENSPPYP00000000143 | AK9 isoform 2. | GUK1 isoform 3. | 0.937 |
| AK9 | NME2 | ENSPPYP00000018934 | ENSPPYP00000005726 | AK9 isoform 2. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.944 |
| AK9 | NME3 | ENSPPYP00000018934 | ENSPPYP00000007881 | AK9 isoform 2. | Nucleoside diphosphate kinase. | 0.944 |
| AK9 | NME4 | ENSPPYP00000018934 | ENSPPYP00000007822 | AK9 isoform 2. | Nucleoside diphosphate kinase. | 0.944 |
| AK9 | NME6 | ENSPPYP00000018934 | ENSPPYP00000015557 | AK9 isoform 2. | Nucleoside diphosphate kinase. | 0.944 |
| AK9 | RRM1 | ENSPPYP00000018934 | ENSPPYP00000004146 | AK9 isoform 2. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.989 |
| AK9 | RRM2 | ENSPPYP00000018934 | ENSPPYP00000014130 | AK9 isoform 2. | Ribonucleotide reductase regulatory subunit M2. | 0.983 |
| AK9 | RRM2B | ENSPPYP00000018934 | ENSPPYP00000021083 | AK9 isoform 2. | Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity). Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.983 |
