DEPTOR protein (Pongo abelii) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

DEPTOR

DEPTOR isoform 1. (408 aa)

Predicted Functional Partners:

MLST8

0.997

RPTOR

0.997

RICTOR

0.983

AKT1S1

0.980

MAPKAP1

0.975

RHEB

0.969

RPS6KB1

0.951

RRAGA

0.951

RRAGC

0.939

ATG13

0.934

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	ATG13	ENSPPYP00000011493	ENSPPYP00000003811	AKT1S1 isoform 1.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.947
AKT1S1	DEPTOR	ENSPPYP00000011493	ENSPPYP00000021144	AKT1S1 isoform 1.	DEPTOR isoform 1.	0.980
AKT1S1	MAPKAP1	ENSPPYP00000011493	ENSPPYP00000021975	AKT1S1 isoform 1.	Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]	0.977
AKT1S1	MLST8	ENSPPYP00000011493	ENSPPYP00000007913	AKT1S1 isoform 1.	MTOR associated protein, LST8 homolog.	0.999
AKT1S1	RHEB	ENSPPYP00000011493	ENSPPYP00000020403	AKT1S1 isoform 1.	RHEB isoform 1.	0.987
AKT1S1	RICTOR	ENSPPYP00000011493	ENSPPYP00000017219	AKT1S1 isoform 1.	RICTOR isoform 1.	0.880
AKT1S1	RPS6KB1	ENSPPYP00000011493	ENSPPYP00000009887	AKT1S1 isoform 1.	T0040019 isoform 1.	0.965
AKT1S1	RPTOR	ENSPPYP00000011493	ENSPPYP00000024617	AKT1S1 isoform 1.	RPTOR isoform 4.	0.999
AKT1S1	RRAGA	ENSPPYP00000011493	ENSPPYP00000021503	AKT1S1 isoform 1.	Ras related GTP binding A.	0.992
AKT1S1	RRAGC	ENSPPYP00000011493	ENSPPYP00000001752	AKT1S1 isoform 1.	RRAGC isoform 1.	0.990
ATG13	AKT1S1	ENSPPYP00000003811	ENSPPYP00000011493	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	AKT1S1 isoform 1.	0.947
ATG13	DEPTOR	ENSPPYP00000003811	ENSPPYP00000021144	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	DEPTOR isoform 1.	0.934
ATG13	MLST8	ENSPPYP00000003811	ENSPPYP00000007913	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	MTOR associated protein, LST8 homolog.	0.975
ATG13	RHEB	ENSPPYP00000003811	ENSPPYP00000020403	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RHEB isoform 1.	0.674
ATG13	RPTOR	ENSPPYP00000003811	ENSPPYP00000024617	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RPTOR isoform 4.	0.986
ATG13	RRAGA	ENSPPYP00000003811	ENSPPYP00000021503	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Ras related GTP binding A.	0.586
ATG13	RRAGC	ENSPPYP00000003811	ENSPPYP00000001752	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RRAGC isoform 1.	0.600
DEPTOR	AKT1S1	ENSPPYP00000021144	ENSPPYP00000011493	DEPTOR isoform 1.	AKT1S1 isoform 1.	0.980
DEPTOR	ATG13	ENSPPYP00000021144	ENSPPYP00000003811	DEPTOR isoform 1.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.934
DEPTOR	MAPKAP1	ENSPPYP00000021144	ENSPPYP00000021975	DEPTOR isoform 1.	Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]	0.975