| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | CDKN2B | ENSPPYP00000009402 | ENSPPYP00000021478 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Cyclin dependent kinase inhibitor 2B. | 0.473 |
| BRCA1 | EP300 | ENSPPYP00000009402 | ENSPPYP00000013236 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | EP300 isoform 1. | 0.934 |
| BRCA1 | MYC | ENSPPYP00000009402 | ENSPPYP00000021181 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | MYC isoform 1. | 0.958 |
| CDKN2B | BRCA1 | ENSPPYP00000021478 | ENSPPYP00000009402 | Cyclin dependent kinase inhibitor 2B. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.473 |
| CDKN2B | CTNNB1 | ENSPPYP00000021478 | ENSPPYP00000015644 | Cyclin dependent kinase inhibitor 2B. | CTNNB1 isoform 2. | 0.489 |
| CDKN2B | MYC | ENSPPYP00000021478 | ENSPPYP00000021181 | Cyclin dependent kinase inhibitor 2B. | MYC isoform 1. | 0.986 |
| CTNNB1 | CDKN2B | ENSPPYP00000015644 | ENSPPYP00000021478 | CTNNB1 isoform 2. | Cyclin dependent kinase inhibitor 2B. | 0.489 |
| CTNNB1 | EP300 | ENSPPYP00000015644 | ENSPPYP00000013236 | CTNNB1 isoform 2. | EP300 isoform 1. | 0.996 |
| CTNNB1 | FBXW7 | ENSPPYP00000015644 | ENSPPYP00000016901 | CTNNB1 isoform 2. | FBXW7 isoform 8. | 0.846 |
| CTNNB1 | GSK3B | ENSPPYP00000015644 | ENSPPYP00000015105 | CTNNB1 isoform 2. | GSK3B isoform 2; Belongs to the protein kinase superfamily. | 0.998 |
| CTNNB1 | MAPK3 | ENSPPYP00000015644 | ENSPPYP00000008184 | CTNNB1 isoform 2. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.679 |
| CTNNB1 | MYC | ENSPPYP00000015644 | ENSPPYP00000021181 | CTNNB1 isoform 2. | MYC isoform 1. | 0.967 |
| EP300 | BRCA1 | ENSPPYP00000013236 | ENSPPYP00000009402 | EP300 isoform 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.934 |
| EP300 | CTNNB1 | ENSPPYP00000013236 | ENSPPYP00000015644 | EP300 isoform 1. | CTNNB1 isoform 2. | 0.996 |
| EP300 | MAPK3 | ENSPPYP00000013236 | ENSPPYP00000008184 | EP300 isoform 1. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.570 |
| EP300 | MAX | ENSPPYP00000013236 | ENSPPYP00000006719 | EP300 isoform 1. | MYC associated factor X. | 0.778 |
| EP300 | MYC | ENSPPYP00000013236 | ENSPPYP00000021181 | EP300 isoform 1. | MYC isoform 1. | 0.961 |
| EP300 | ZBTB17 | ENSPPYP00000013236 | ENSPPYP00000002128 | EP300 isoform 1. | Zinc finger and BTB domain containing 17. | 0.596 |
| FBXW7 | CTNNB1 | ENSPPYP00000016901 | ENSPPYP00000015644 | FBXW7 isoform 8. | CTNNB1 isoform 2. | 0.846 |
| FBXW7 | GSK3B | ENSPPYP00000016901 | ENSPPYP00000015105 | FBXW7 isoform 8. | GSK3B isoform 2; Belongs to the protein kinase superfamily. | 0.484 |
