STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)    
Predicted Functional Partners:
GNAS
GNAS isoform 2.
   
 0.988
GNAL
GNAL isoform 3.
   
 0.987
ADCY1
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
     
0.975
GNAI2
GNAI2 isoform 1.
   
 0.969
ADCY3
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
     
0.965
GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]
   
 0.964
CALML5
Calmodulin like 5.
    
 0.963
CALML3
CALML3 isoform 1; Belongs to the calmodulin family.
    
 0.963
PRKACG
Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.
   
 0.961
GNAO1
GNAO1 isoform 1.
   
 0.959
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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