STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAPK15MAPK15 isoform 3. (546 aa)    
Predicted Functional Partners:
CLIC3
Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.
   
 
 0.821
RFX2
DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T.
   
  
 0.796
ABCG4
ATP binding cassette subfamily G member 4.
    
 
 0.792
ALOX5AP
ALOX5AP isoform 2.
      
 0.786
RUSC2
RUSC2 isoform 1.
   
  
 0.778
MECP2
Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
    
 
 0.714
CIDEB
Cell death inducing DFFA like effector b.
      
 0.713
LTA4H
Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family.
      
 0.710
CLIC1
Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.
   
 
 0.671
CLIC2
Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.
    
 
 0.648
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.