| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGXT | AGXT2 | ENSPPYP00000014927 | ENSPPYP00000017192 | Serine--pyruvate aminotransferase. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.818 |
| AGXT | GRHPR | ENSPPYP00000014927 | ENSPPYP00000021363 | Serine--pyruvate aminotransferase. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.958 |
| AGXT | HAO1 | ENSPPYP00000014927 | ENSPPYP00000011960 | Serine--pyruvate aminotransferase. | HAO1 isoform 1. | 0.800 |
| AGXT | HAO2 | ENSPPYP00000014927 | ENSPPYP00000001125 | Serine--pyruvate aminotransferase. | HAO2 isoform 1. | 0.813 |
| AGXT | HOGA1 | ENSPPYP00000014927 | ENSPPYP00000023748 | Serine--pyruvate aminotransferase. | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1. | 0.785 |
| AGXT | SDS | ENSPPYP00000014927 | ENSPPYP00000005692 | Serine--pyruvate aminotransferase. | Serine dehydratase. | 0.433 |
| AGXT | SDSL | ENSPPYP00000014927 | ENSPPYP00000005693 | Serine--pyruvate aminotransferase. | Serine dehydratase like. | 0.428 |
| AGXT2 | AGXT | ENSPPYP00000017192 | ENSPPYP00000014927 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Serine--pyruvate aminotransferase. | 0.818 |
| AGXT2 | GRHPR | ENSPPYP00000017192 | ENSPPYP00000021363 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.928 |
| AGXT2 | HAO1 | ENSPPYP00000017192 | ENSPPYP00000011960 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | HAO1 isoform 1. | 0.928 |
| AGXT2 | HAO2 | ENSPPYP00000017192 | ENSPPYP00000001125 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | HAO2 isoform 1. | 0.938 |
| AGXT2 | HOGA1 | ENSPPYP00000017192 | ENSPPYP00000023748 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1. | 0.910 |
| AGXT2 | HYI | ENSPPYP00000017192 | ENSPPYP00000001674 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.814 |
| AGXT2 | SDS | ENSPPYP00000017192 | ENSPPYP00000005692 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Serine dehydratase. | 0.842 |
| AGXT2 | SDSL | ENSPPYP00000017192 | ENSPPYP00000005693 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Serine dehydratase like. | 0.842 |
| GLO1 | GRHPR | ENSPPYP00000018532 | ENSPPYP00000021363 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.926 |
| GLO1 | HAO1 | ENSPPYP00000018532 | ENSPPYP00000011960 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | HAO1 isoform 1. | 0.511 |
| GLO1 | HAO2 | ENSPPYP00000018532 | ENSPPYP00000001125 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | HAO2 isoform 1. | 0.511 |
| GLO1 | PGP | ENSPPYP00000018532 | ENSPPYP00000007915 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | PGP isoform 1; Belongs to the HAD-like hydrolase superfamily. | 0.487 |
| GLO1 | SDS | ENSPPYP00000018532 | ENSPPYP00000005692 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Serine dehydratase. | 0.823 |
