STOML2 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DELE1	PHB2	ENSPPYP00000017776	ENSPPYP00000004803	DAP3 binding cell death enhancer 1.	Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...]	0.832
DELE1	STOML2	ENSPPYP00000017776	ENSPPYP00000021405	DAP3 binding cell death enhancer 1.	STOML2 isoform 3.	0.853
HSBP1	LOC100447565	ENSPPYP00000008675	ENSPPYP00000018756	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	SMS isoform 1.	0.717
HSBP1	PCNA	ENSPPYP00000008675	ENSPPYP00000012059	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.418
HSBP1	SMS	ENSPPYP00000008675	ENSPPYP00000022584	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	Spermine synthase isoform X2.	0.717
HSBP1	STOML2	ENSPPYP00000008675	ENSPPYP00000021405	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	STOML2 isoform 3.	0.787
LOC100447565	HSBP1	ENSPPYP00000018756	ENSPPYP00000008675	SMS isoform 1.	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	0.717
LOC100447565	PCNA	ENSPPYP00000018756	ENSPPYP00000012059	SMS isoform 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.583
LOC100447565	SMS	ENSPPYP00000018756	ENSPPYP00000022584	SMS isoform 1.	Spermine synthase isoform X2.	0.900
LOC100447565	STOML2	ENSPPYP00000018756	ENSPPYP00000021405	SMS isoform 1.	STOML2 isoform 3.	0.767
MRPS7	PHB	ENSPPYP00000009683	ENSPPYP00000010009	MRPS7 isoform 2.	Prohibitin.	0.593
MRPS7	STOML2	ENSPPYP00000009683	ENSPPYP00000021405	MRPS7 isoform 2.	STOML2 isoform 3.	0.722
MRPS7	YME1L1	ENSPPYP00000009683	ENSPPYP00000002519	MRPS7 isoform 2.	YME1L1 isoform 2.	0.469
PARL	PHB	ENSPPYP00000024436	ENSPPYP00000010009	Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).	Prohibitin.	0.498
PARL	PHB2	ENSPPYP00000024436	ENSPPYP00000004803	Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).	Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...]	0.771
PARL	STOML2	ENSPPYP00000024436	ENSPPYP00000021405	Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).	STOML2 isoform 3.	0.943
PARL	YME1L1	ENSPPYP00000024436	ENSPPYP00000002519	Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).	YME1L1 isoform 2.	0.838
PCNA	HSBP1	ENSPPYP00000012059	ENSPPYP00000008675	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).	0.418
PCNA	LOC100447565	ENSPPYP00000012059	ENSPPYP00000018756	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	SMS isoform 1.	0.583
PCNA	SMS	ENSPPYP00000012059	ENSPPYP00000022584	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Spermine synthase isoform X2.	0.583