DDX58 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSPPYP00000017559	ENSPPYP00000018899	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...]	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	0.999
ATG12	DDX58	ENSPPYP00000017559	ENSPPYP00000021455	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...]	DDX58 isoform 2.	0.952
ATG12	IFIH1	ENSPPYP00000017559	ENSPPYP00000014381	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...]	IFIH1 isoform 1.	0.409
ATG12	MAVS	ENSPPYP00000017559	ENSPPYP00000012072	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...]	MAVS isoform 2.	0.977
ATG5	ATG12	ENSPPYP00000018899	ENSPPYP00000017559	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...]	0.999
ATG5	DDX58	ENSPPYP00000018899	ENSPPYP00000021455	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	DDX58 isoform 2.	0.951
ATG5	MAVS	ENSPPYP00000018899	ENSPPYP00000012072	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	MAVS isoform 2.	0.972
CR201_G0039615	DDX58	ENSPPYP00000013953	ENSPPYP00000021455	EIF2AK2 isoform 5.	DDX58 isoform 2.	0.958
CR201_G0039615	IFIH1	ENSPPYP00000013953	ENSPPYP00000014381	EIF2AK2 isoform 5.	IFIH1 isoform 1.	0.878
CR201_G0039615	ISG15	ENSPPYP00000013953	ENSPPYP00000002343	EIF2AK2 isoform 5.	ISG15 ubiquitin like modifier.	0.979
CR201_G0039615	MAVS	ENSPPYP00000013953	ENSPPYP00000012072	EIF2AK2 isoform 5.	MAVS isoform 2.	0.972
CR201_G0039615	OASL	ENSPPYP00000013953	ENSPPYP00000005747	EIF2AK2 isoform 5.	2'-5'-oligoadenylate synthetase like.	0.567
CR201_G0039615	RNF135	ENSPPYP00000013953	ENSPPYP00000009157	EIF2AK2 isoform 5.	Ring finger protein 135.	0.483
CR201_G0039615	TRAF6	ENSPPYP00000013953	ENSPPYP00000003845	EIF2AK2 isoform 5.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.624
CR201_G0039615	TRIM25	ENSPPYP00000013953	ENSPPYP00000009268	EIF2AK2 isoform 5.	Tripartite motif containing 25.	0.620
DDX58	ATG12	ENSPPYP00000021455	ENSPPYP00000017559	DDX58 isoform 2.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...]	0.952
DDX58	ATG5	ENSPPYP00000021455	ENSPPYP00000018899	DDX58 isoform 2.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	0.951
DDX58	CR201_G0039615	ENSPPYP00000021455	ENSPPYP00000013953	DDX58 isoform 2.	EIF2AK2 isoform 5.	0.958
DDX58	IFIH1	ENSPPYP00000021455	ENSPPYP00000014381	DDX58 isoform 2.	IFIH1 isoform 1.	0.952
DDX58	ISG15	ENSPPYP00000021455	ENSPPYP00000002343	DDX58 isoform 2.	ISG15 ubiquitin like modifier.	0.999