C9orf72 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG101	ATG13	ENSPPYP00000005179	ENSPPYP00000003811	ATG101 isoform 1.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.999
ATG101	C9orf72	ENSPPYP00000005179	ENSPPYP00000021460	ATG101 isoform 1.	C9orf72-SMCR8 complex subunit.	0.958
ATG101	RB1CC1	ENSPPYP00000005179	ENSPPYP00000020840	ATG101 isoform 1.	RB1CC1 isoform 1.	0.999
ATG101	ULK1	ENSPPYP00000005179	ENSPPYP00000005848	ATG101 isoform 1.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.999
ATG101	ULK2	ENSPPYP00000005179	ENSPPYP00000009920	ATG101 isoform 1.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.997
ATG101	WDR41	ENSPPYP00000005179	ENSPPYP00000024163	ATG101 isoform 1.	WDR41 isoform 3.	0.545
ATG13	ATG101	ENSPPYP00000003811	ENSPPYP00000005179	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	ATG101 isoform 1.	0.999
ATG13	C9orf72	ENSPPYP00000003811	ENSPPYP00000021460	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	C9orf72-SMCR8 complex subunit.	0.985
ATG13	RB1CC1	ENSPPYP00000003811	ENSPPYP00000020840	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RB1CC1 isoform 1.	0.999
ATG13	ULK1	ENSPPYP00000003811	ENSPPYP00000005848	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.999
ATG13	ULK2	ENSPPYP00000003811	ENSPPYP00000009920	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.998
ATG13	WDR41	ENSPPYP00000003811	ENSPPYP00000024163	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	WDR41 isoform 3.	0.489
C9orf72	ATG101	ENSPPYP00000021460	ENSPPYP00000005179	C9orf72-SMCR8 complex subunit.	ATG101 isoform 1.	0.958
C9orf72	ATG13	ENSPPYP00000021460	ENSPPYP00000003811	C9orf72-SMCR8 complex subunit.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.985
C9orf72	LMLN	ENSPPYP00000021460	ENSPPYP00000016171	C9orf72-SMCR8 complex subunit.	Leishmanolysin-like peptidase.	0.801
C9orf72	RAB1A	ENSPPYP00000021460	ENSPPYP00000013783	C9orf72-SMCR8 complex subunit.	RAB1A isoform 1.	0.926
C9orf72	RAB39B	ENSPPYP00000021460	ENSPPYP00000023401	C9orf72-SMCR8 complex subunit.	RAB39B, member RAS oncogene family.	0.981
C9orf72	RAB8A	ENSPPYP00000021460	ENSPPYP00000010852	C9orf72-SMCR8 complex subunit.	Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...]	0.961
C9orf72	RB1CC1	ENSPPYP00000021460	ENSPPYP00000020840	C9orf72-SMCR8 complex subunit.	RB1CC1 isoform 1.	0.976
C9orf72	ULK1	ENSPPYP00000021460	ENSPPYP00000005848	C9orf72-SMCR8 complex subunit.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.982