STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFNB1Interferon beta 1. (187 aa)    
Predicted Functional Partners:
IFNAR1
IFNAR1 isoform 2.
   
 0.994
IRF7
IRF7 isoform 12.
   
 
 0.977
CR201_G0027342
T0093957 isoform 2.
   
 0.947
JAK1
Tyrosine-protein kinase.
   
 
 0.913
IFNGR1
IFNGR1 isoform 1.
  
 
 0.884
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.876
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
   
  
 0.862
IRF3
IRF3 isoform 6.
     
 0.849
JAK2
Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]
   
 
 0.840
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 
 0.825
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.