Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DOCK8DOCK8 isoform 2; Belongs to the DOCK family. (2024 aa)    
Predicted Functional Partners:
LRCH1
LRCH1 isoform 2.
   
 
 0.930
CR201_G0040309
LRCH4 isoform 3.
   
 
 0.925
LRCH3
LRCH3 isoform 8.
   
 
 0.921
RHOJ
Ras homolog family member J.
   
 0.855
DOCK6
DOCK6 isoform 2; Belongs to the DOCK family.
    
   0.840
CDC42
Cell division cycle 42.
   
 0.838
DOCK7
DOCK7 isoform 6; Belongs to the DOCK family.
    
   0.826
ARPC3
Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
    
 
 0.823
LRCH2
LRCH2 isoform 1.
   
 
 0.816
RHOQ
RHOQ isoform 1.
   
 0.807
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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