Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TJP2TJP2 isoform 3; Belongs to the MAGUK family. (1186 aa)    
Predicted Functional Partners:
TJP1
TJP1 isoform 1; Belongs to the MAGUK family.
   
0.985
AFDN
AFDN isoform 9.
   
 0.975
F11R
F11R isoform 1.
   
 0.963
OCLN
Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
   
 
 0.909
RAPGEF2
RAPGEF2 isoform 1.
     
 0.909
YAP1
YAP1 isoform 2.
   
 0.880
WWTR1
WW domain containing transcription regulator 1.
   
 0.840
CASP3
CASP3 isoform 1; Belongs to the peptidase C14A family.
    
 0.816
GJA1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
 0.761
CGN
CGN isoform 4.
   
 0.748
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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