TLE4 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0044248	HDAC1	ENSPPYP00000010505	ENSPPYP00000001838	AES isoform 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	0.590
CR201_G0044248	LEF1	ENSPPYP00000010505	ENSPPYP00000016739	AES isoform 2.	Lymphoid enhancer binding factor 1.	0.628
CR201_G0044248	TCF7	ENSPPYP00000010505	ENSPPYP00000017648	AES isoform 2.	TCF7 isoform 6.	0.586
CR201_G0044248	TLE1	ENSPPYP00000010505	ENSPPYP00000021643	AES isoform 2.	TLE1 isoform 1.	0.955
CR201_G0044248	TLE2	ENSPPYP00000010505	ENSPPYP00000010504	AES isoform 2.	TLE2 isoform 1.	0.939
CR201_G0044248	TLE3	ENSPPYP00000010505	ENSPPYP00000007485	AES isoform 2.	TLE family member 3, transcriptional corepressor.	0.861
CR201_G0044248	TLE4	ENSPPYP00000010505	ENSPPYP00000021638	AES isoform 2.	TLE4 isoform 4.	0.939
FRMD3	PSAT1	ENSPPYP00000021647	ENSPPYP00000021636	FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.	Phosphoserine aminotransferase.	0.898
FRMD3	TLE1	ENSPPYP00000021647	ENSPPYP00000021643	FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.	TLE1 isoform 1.	0.901
FRMD3	TLE2	ENSPPYP00000021647	ENSPPYP00000010504	FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.	TLE2 isoform 1.	0.510
FRMD3	TLE4	ENSPPYP00000021647	ENSPPYP00000021638	FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.	TLE4 isoform 4.	0.866
HDAC1	CR201_G0044248	ENSPPYP00000001838	ENSPPYP00000010505	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	AES isoform 2.	0.590
HDAC1	LEF1	ENSPPYP00000001838	ENSPPYP00000016739	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	Lymphoid enhancer binding factor 1.	0.641
HDAC1	RBPJ	ENSPPYP00000001838	ENSPPYP00000016373	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]	0.955
HDAC1	TCF7	ENSPPYP00000001838	ENSPPYP00000017648	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	TCF7 isoform 6.	0.564
HDAC1	TLE1	ENSPPYP00000001838	ENSPPYP00000021643	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	TLE1 isoform 1.	0.964
HDAC1	TLE2	ENSPPYP00000001838	ENSPPYP00000010504	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	TLE2 isoform 1.	0.590
HDAC1	TLE3	ENSPPYP00000001838	ENSPPYP00000007485	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	TLE family member 3, transcriptional corepressor.	0.935
HDAC1	TLE4	ENSPPYP00000001838	ENSPPYP00000021638	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	TLE4 isoform 4.	0.914
LEF1	CR201_G0044248	ENSPPYP00000016739	ENSPPYP00000010505	Lymphoid enhancer binding factor 1.	AES isoform 2.	0.628