| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C4 | CYP17A1 | ENSPPYP00000002376 | ENSPPYP00000003038 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.928 |
| AKR1C4 | HSD17B11 | ENSPPYP00000002376 | ENSPPYP00000016651 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.912 |
| AKR1C4 | HSD17B3 | ENSPPYP00000002376 | ENSPPYP00000021754 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.932 |
| AKR1C4 | SRD5A1 | ENSPPYP00000002376 | ENSPPYP00000017128 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). | 0.931 |
| AKR1C4 | SRD5A2 | ENSPPYP00000002376 | ENSPPYP00000013975 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). | 0.927 |
| CYP11B1 | CYP17A1 | ENSPPYP00000021229 | ENSPPYP00000003038 | CYP11B2 isoform 1. | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.949 |
| CYP11B1 | CYP19A1 | ENSPPYP00000021229 | ENSPPYP00000007338 | CYP11B2 isoform 1. | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.937 |
| CYP11B1 | HSD17B2 | ENSPPYP00000021229 | ENSPPYP00000008566 | CYP11B2 isoform 1. | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.921 |
| CYP11B1 | HSD17B3 | ENSPPYP00000021229 | ENSPPYP00000021754 | CYP11B2 isoform 1. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.942 |
| CYP11B1 | HSD17B8 | ENSPPYP00000021229 | ENSPPYP00000019326 | CYP11B2 isoform 1. | HSD17B8 isoform 1. | 0.917 |
| CYP11B1 | HSD3B1 | ENSPPYP00000021229 | ENSPPYP00000001124 | CYP11B2 isoform 1. | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.944 |
| CYP11B1 | SRD5A1 | ENSPPYP00000021229 | ENSPPYP00000017128 | CYP11B2 isoform 1. | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). | 0.925 |
| CYP11B1 | SRD5A2 | ENSPPYP00000021229 | ENSPPYP00000013975 | CYP11B2 isoform 1. | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). | 0.918 |
| CYP17A1 | AKR1C4 | ENSPPYP00000003038 | ENSPPYP00000002376 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | 0.928 |
| CYP17A1 | CYP11B1 | ENSPPYP00000003038 | ENSPPYP00000021229 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | CYP11B2 isoform 1. | 0.949 |
| CYP17A1 | CYP19A1 | ENSPPYP00000003038 | ENSPPYP00000007338 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.953 |
| CYP17A1 | HSD17B11 | ENSPPYP00000003038 | ENSPPYP00000016651 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.919 |
| CYP17A1 | HSD17B2 | ENSPPYP00000003038 | ENSPPYP00000008566 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.940 |
| CYP17A1 | HSD17B3 | ENSPPYP00000003038 | ENSPPYP00000021754 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.964 |
| CYP17A1 | HSD17B8 | ENSPPYP00000003038 | ENSPPYP00000019326 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | HSD17B8 isoform 1. | 0.932 |
