| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SMAD2 | SMAD3 | ENSPPYP00000010275 | ENSPPYP00000007465 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD4 | ENSPPYP00000010275 | ENSPPYP00000010297 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD7 | ENSPPYP00000010275 | ENSPPYP00000010278 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.991 |
| SMAD2 | SMURF1 | ENSPPYP00000010275 | ENSPPYP00000019458 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | E3 ubiquitin-protein ligase. | 0.892 |
| SMAD2 | SMURF2 | ENSPPYP00000010275 | ENSPPYP00000009604 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | E3 ubiquitin-protein ligase. | 0.992 |
| SMAD2 | TGFB1 | ENSPPYP00000010275 | ENSPPYP00000011208 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.878 |
| SMAD2 | TGFB2 | ENSPPYP00000010275 | ENSPPYP00000000219 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.755 |
| SMAD2 | TGFB3 | ENSPPYP00000010275 | ENSPPYP00000006835 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.686 |
| SMAD2 | TGFBR1 | ENSPPYP00000010275 | ENSPPYP00000021783 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.998 |
| SMAD2 | TGFBR2 | ENSPPYP00000010275 | ENSPPYP00000015718 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.988 |
| SMAD3 | SMAD2 | ENSPPYP00000007465 | ENSPPYP00000010275 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.999 |
| SMAD3 | SMAD4 | ENSPPYP00000007465 | ENSPPYP00000010297 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD3 | SMAD7 | ENSPPYP00000007465 | ENSPPYP00000010278 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.990 |
| SMAD3 | SMURF1 | ENSPPYP00000007465 | ENSPPYP00000019458 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.937 |
| SMAD3 | SMURF2 | ENSPPYP00000007465 | ENSPPYP00000009604 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.990 |
| SMAD3 | TGFB1 | ENSPPYP00000007465 | ENSPPYP00000011208 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.880 |
| SMAD3 | TGFB2 | ENSPPYP00000007465 | ENSPPYP00000000219 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.741 |
| SMAD3 | TGFB3 | ENSPPYP00000007465 | ENSPPYP00000006835 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.664 |
| SMAD3 | TGFBR1 | ENSPPYP00000007465 | ENSPPYP00000021783 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.996 |
| SMAD3 | TGFBR2 | ENSPPYP00000007465 | ENSPPYP00000015718 | Mothers against decapentaplegic homolog. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.986 |
