| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0001249 | ENSPPYP00000016598 | ENSPPYP00000005584 | ENSPPYP00000016598 | TXNRD1 isoform 17. | annotation not available | 0.904 |
| CR201_G0001249 | PRDX1 | ENSPPYP00000005584 | ENSPPYP00000001637 | TXNRD1 isoform 17. | PRDX1 isoform 2. | 0.500 |
| CR201_G0001249 | PRDX2 | ENSPPYP00000005584 | ENSPPYP00000024125 | TXNRD1 isoform 17. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.473 |
| CR201_G0001249 | PRDX5 | ENSPPYP00000005584 | ENSPPYP00000003590 | TXNRD1 isoform 17. | Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | 0.637 |
| CR201_G0001249 | TXN | ENSPPYP00000005584 | ENSPPYP00000021834 | TXNRD1 isoform 17. | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.904 |
| DAXX | ENSPPYP00000016598 | ENSPPYP00000019339 | ENSPPYP00000016598 | Death domain associated protein. | annotation not available | 0.908 |
| DAXX | MAP3K5 | ENSPPYP00000019339 | ENSPPYP00000019077 | Death domain associated protein. | MAP3K5 isoform 1. | 0.995 |
| DAXX | TXN | ENSPPYP00000019339 | ENSPPYP00000021834 | Death domain associated protein. | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.908 |
| ENSPPYP00000016598 | CR201_G0001249 | ENSPPYP00000016598 | ENSPPYP00000005584 | annotation not available | TXNRD1 isoform 17. | 0.904 |
| ENSPPYP00000016598 | DAXX | ENSPPYP00000016598 | ENSPPYP00000019339 | annotation not available | Death domain associated protein. | 0.908 |
| ENSPPYP00000016598 | GSR | ENSPPYP00000016598 | ENSPPYP00000020725 | annotation not available | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.719 |
| ENSPPYP00000016598 | MAP3K5 | ENSPPYP00000016598 | ENSPPYP00000019077 | annotation not available | MAP3K5 isoform 1. | 0.995 |
| ENSPPYP00000016598 | PRDX1 | ENSPPYP00000016598 | ENSPPYP00000001637 | annotation not available | PRDX1 isoform 2. | 0.942 |
| ENSPPYP00000016598 | PRDX2 | ENSPPYP00000016598 | ENSPPYP00000024125 | annotation not available | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.920 |
| ENSPPYP00000016598 | PRDX5 | ENSPPYP00000016598 | ENSPPYP00000003590 | annotation not available | Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | 0.804 |
| ENSPPYP00000016598 | TXN | ENSPPYP00000016598 | ENSPPYP00000021834 | annotation not available | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.900 |
| ENSPPYP00000016598 | TXNIP | ENSPPYP00000016598 | ENSPPYP00000001080 | annotation not available | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] | 0.995 |
| ENSPPYP00000016598 | TXNRD3 | ENSPPYP00000016598 | ENSPPYP00000015043 | annotation not available | TXNRD3 isoform 1. | 0.776 |
| GSR | ENSPPYP00000016598 | ENSPPYP00000020725 | ENSPPYP00000016598 | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | annotation not available | 0.719 |
| GSR | PRDX1 | ENSPPYP00000020725 | ENSPPYP00000001637 | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | PRDX1 isoform 2. | 0.610 |
