| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD14 | LY96 | ENSPPYP00000017732 | ENSPPYP00000020954 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lymphocyte antigen 96. | 0.964 |
| CD14 | TLR2 | ENSPPYP00000017732 | ENSPPYP00000016910 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.977 |
| CD14 | TLR4 | ENSPPYP00000017732 | ENSPPYP00000021908 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.973 |
| CD14 | TLR6 | ENSPPYP00000017732 | ENSPPYP00000016388 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.489 |
| HMGB1 | LY96 | ENSPPYP00000006318 | ENSPPYP00000020954 | High mobility group box 1. | Lymphocyte antigen 96. | 0.770 |
| HMGB1 | TLR2 | ENSPPYP00000006318 | ENSPPYP00000016910 | High mobility group box 1. | Toll-like receptor. | 0.948 |
| HMGB1 | TLR4 | ENSPPYP00000006318 | ENSPPYP00000021908 | High mobility group box 1. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.989 |
| IRAK4 | LY96 | ENSPPYP00000005053 | ENSPPYP00000020954 | IRAK4 isoform 6. | Lymphocyte antigen 96. | 0.483 |
| IRAK4 | MYD88 | ENSPPYP00000005053 | ENSPPYP00000015673 | IRAK4 isoform 6. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK4 | TICAM1 | ENSPPYP00000005053 | ENSPPYP00000010561 | IRAK4 isoform 6. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.936 |
| IRAK4 | TIRAP | ENSPPYP00000005053 | ENSPPYP00000004627 | IRAK4 isoform 6. | TIR domain containing adaptor protein. | 0.989 |
| IRAK4 | TLR2 | ENSPPYP00000005053 | ENSPPYP00000016910 | IRAK4 isoform 6. | Toll-like receptor. | 0.699 |
| IRAK4 | TLR4 | ENSPPYP00000005053 | ENSPPYP00000021908 | IRAK4 isoform 6. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.984 |
| IRAK4 | TLR6 | ENSPPYP00000005053 | ENSPPYP00000016388 | IRAK4 isoform 6. | Toll-like receptor. | 0.541 |
| LY96 | CD14 | ENSPPYP00000020954 | ENSPPYP00000017732 | Lymphocyte antigen 96. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.964 |
| LY96 | HMGB1 | ENSPPYP00000020954 | ENSPPYP00000006318 | Lymphocyte antigen 96. | High mobility group box 1. | 0.770 |
| LY96 | IRAK4 | ENSPPYP00000020954 | ENSPPYP00000005053 | Lymphocyte antigen 96. | IRAK4 isoform 6. | 0.483 |
| LY96 | MYD88 | ENSPPYP00000020954 | ENSPPYP00000015673 | Lymphocyte antigen 96. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.968 |
| LY96 | TICAM1 | ENSPPYP00000020954 | ENSPPYP00000010561 | Lymphocyte antigen 96. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.949 |
| LY96 | TIRAP | ENSPPYP00000020954 | ENSPPYP00000004627 | Lymphocyte antigen 96. | TIR domain containing adaptor protein. | 0.953 |
