| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APBA1 | SNAP25 | ENSPPYP00000021589 | ENSPPYP00000011970 | APBA1 isoform 1. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | 0.584 |
| APBA1 | STX1A | ENSPPYP00000021589 | ENSPPYP00000019613 | APBA1 isoform 1. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.631 |
| APBA1 | STX1B | ENSPPYP00000021589 | ENSPPYP00000008248 | APBA1 isoform 1. | STX1B isoform 1; Belongs to the syntaxin family. | 0.592 |
| APBA1 | STX2 | ENSPPYP00000021589 | ENSPPYP00000005839 | APBA1 isoform 1. | STX2 isoform 2; Belongs to the syntaxin family. | 0.453 |
| APBA1 | STX3 | ENSPPYP00000021589 | ENSPPYP00000003718 | APBA1 isoform 1. | STX3 isoform 3; Belongs to the syntaxin family. | 0.453 |
| APBA1 | STX4 | ENSPPYP00000021589 | ENSPPYP00000008249 | APBA1 isoform 1. | STX4 isoform 4; Belongs to the syntaxin family. | 0.453 |
| APBA1 | STXBP1 | ENSPPYP00000021589 | ENSPPYP00000021991 | APBA1 isoform 1. | Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). | 0.927 |
| APBA1 | VAMP2 | ENSPPYP00000021589 | ENSPPYP00000008938 | APBA1 isoform 1. | VAMP2 isoform 2. | 0.424 |
| APBA2 | SNAP25 | ENSPPYP00000007120 | ENSPPYP00000011970 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | 0.557 |
| APBA2 | STX1A | ENSPPYP00000007120 | ENSPPYP00000019613 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.492 |
| APBA2 | STX1B | ENSPPYP00000007120 | ENSPPYP00000008248 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | STX1B isoform 1; Belongs to the syntaxin family. | 0.444 |
| APBA2 | STX2 | ENSPPYP00000007120 | ENSPPYP00000005839 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | STX2 isoform 2; Belongs to the syntaxin family. | 0.406 |
| APBA2 | STX3 | ENSPPYP00000007120 | ENSPPYP00000003718 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | STX3 isoform 3; Belongs to the syntaxin family. | 0.406 |
| APBA2 | STX4 | ENSPPYP00000007120 | ENSPPYP00000008249 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | STX4 isoform 4; Belongs to the syntaxin family. | 0.406 |
| APBA2 | STXBP1 | ENSPPYP00000007120 | ENSPPYP00000021991 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). | 0.885 |
| SNAP25 | APBA1 | ENSPPYP00000011970 | ENSPPYP00000021589 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | APBA1 isoform 1. | 0.584 |
| SNAP25 | APBA2 | ENSPPYP00000011970 | ENSPPYP00000007120 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). | 0.557 |
| SNAP25 | STX19 | ENSPPYP00000011970 | ENSPPYP00000015239 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR). | 0.778 |
| SNAP25 | STX1A | ENSPPYP00000011970 | ENSPPYP00000019613 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.999 |
| SNAP25 | STX1B | ENSPPYP00000011970 | ENSPPYP00000008248 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | STX1B isoform 1; Belongs to the syntaxin family. | 0.998 |
