Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PIP5KL1PIP5KL1 isoform 1. (439 aa)    
Predicted Functional Partners:
SACM1L
Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity).
    
 0.921
PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.
    
0.920
PTEN
Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.914
CR201_G0044279
PIP5K1C isoform 1.
    
0.914
ENSPPYP00000018135
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1.
    
0.913
PIP5K1B
PIP5K1B isoform 2.
    
0.913
SYNJ1
SYNJ1 isoform 6.
    
 0.911
SYNJ2
SYNJ2 isoform 1.
    
 0.911
PIP4K2A
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha.
     
0.908
INPP5E
INPP5E isoform 2.
     
 0.908
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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