| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBX3 | CDYL | ENSPPYP00000019856 | ENSPPYP00000018112 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Chromodomain Y like. | 0.432 |
| CBX3 | EHMT1 | ENSPPYP00000019856 | ENSPPYP00000022240 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | EHMT1 isoform 1. | 0.856 |
| CBX3 | EHMT2 | ENSPPYP00000019856 | ENSPPYP00000018412 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | EHMT2 isoform 5. | 0.929 |
| CBX3 | KDM1A | ENSPPYP00000019856 | ENSPPYP00000002023 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.445 |
| CBX3 | SUV39H1 | ENSPPYP00000019856 | ENSPPYP00000022743 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.945 |
| CBX3 | SUV39H2 | ENSPPYP00000019856 | ENSPPYP00000002444 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. | 0.795 |
| CBX3 | TRIM28 | ENSPPYP00000019856 | ENSPPYP00000011777 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | TRIM28 isoform 3. | 0.923 |
| CDYL | CBX3 | ENSPPYP00000018112 | ENSPPYP00000019856 | Chromodomain Y like. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.432 |
| CDYL | CR201_G0037536 | ENSPPYP00000018112 | ENSPPYP00000010840 | Chromodomain Y like. | WIZ isoform 3. | 0.838 |
| CDYL | EHMT1 | ENSPPYP00000018112 | ENSPPYP00000022240 | Chromodomain Y like. | EHMT1 isoform 1. | 0.877 |
| CDYL | EHMT2 | ENSPPYP00000018112 | ENSPPYP00000018412 | Chromodomain Y like. | EHMT2 isoform 5. | 0.913 |
| CDYL | SUV39H1 | ENSPPYP00000018112 | ENSPPYP00000022743 | Chromodomain Y like. | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.689 |
| CDYL | SUV39H2 | ENSPPYP00000018112 | ENSPPYP00000002444 | Chromodomain Y like. | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. | 0.689 |
| CR201_G0037536 | CDYL | ENSPPYP00000010840 | ENSPPYP00000018112 | WIZ isoform 3. | Chromodomain Y like. | 0.838 |
| CR201_G0037536 | EHMT1 | ENSPPYP00000010840 | ENSPPYP00000022240 | WIZ isoform 3. | EHMT1 isoform 1. | 0.849 |
| CR201_G0037536 | EHMT2 | ENSPPYP00000010840 | ENSPPYP00000018412 | WIZ isoform 3. | EHMT2 isoform 5. | 0.949 |
| DLGAP2 | EHMT1 | ENSPPYP00000020501 | ENSPPYP00000022240 | DLGAP2 isoform 3. | EHMT1 isoform 1. | 0.846 |
| EHMT1 | CBX3 | ENSPPYP00000022240 | ENSPPYP00000019856 | EHMT1 isoform 1. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.856 |
| EHMT1 | CDYL | ENSPPYP00000022240 | ENSPPYP00000018112 | EHMT1 isoform 1. | Chromodomain Y like. | 0.877 |
| EHMT1 | CR201_G0037536 | ENSPPYP00000022240 | ENSPPYP00000010840 | EHMT1 isoform 1. | WIZ isoform 3. | 0.849 |
