STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STSSTS isoform 1. (590 aa)    
Predicted Functional Partners:
HSD3B1
HSD3B1 isoform 1; Belongs to the 3-beta-HSD family.
    
 0.936
CYP17A1
CYP17A1 isoform 1; Belongs to the cytochrome P450 family.
     
 0.929
CR201_G0028793
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
     
 0.920
CYP3A4
Cytochrome P450 family 3 subfamily A member 4.
   
 
 0.910
AKR1C8P
Prostaglandin F synthase 1-like isoform X1.
   
 
 0.909
CYP1A1
CYP1A1 isoform 1; Belongs to the cytochrome P450 family.
   
 
 0.909
CYP21A2
CYP21A2 isoform 1; Belongs to the cytochrome P450 family.
     
 0.909
ENSPPYP00000002371
Aldo-keto reductase family 1 member C1 homolog.
   
 
 0.907
CYP3A5
CYP3A43 isoform 5; Belongs to the cytochrome P450 family.
   
 
 0.905
CYP2E1
CYP2E1 isoform 1; Belongs to the cytochrome P450 family.
   
 
 0.902
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.