| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C8P | CR201_G0048502 | ENSPPYP00000002377 | ENSPPYP00000024366 | Prostaglandin F synthase 1-like isoform X1. | CYP3A7 isoform 2. | 0.903 |
| AKR1C8P | CYP17A1 | ENSPPYP00000002377 | ENSPPYP00000003038 | Prostaglandin F synthase 1-like isoform X1. | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.917 |
| AKR1C8P | CYP1A1 | ENSPPYP00000002377 | ENSPPYP00000007536 | Prostaglandin F synthase 1-like isoform X1. | CYP1A1 isoform 1; Belongs to the cytochrome P450 family. | 0.904 |
| AKR1C8P | CYP1A2 | ENSPPYP00000002377 | ENSPPYP00000007537 | Prostaglandin F synthase 1-like isoform X1. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.904 |
| AKR1C8P | CYP2E1 | ENSPPYP00000002377 | ENSPPYP00000003264 | Prostaglandin F synthase 1-like isoform X1. | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.903 |
| AKR1C8P | CYP3A4 | ENSPPYP00000002377 | ENSPPYP00000019486 | Prostaglandin F synthase 1-like isoform X1. | Cytochrome P450 family 3 subfamily A member 4. | 0.903 |
| AKR1C8P | HSD3B1 | ENSPPYP00000002377 | ENSPPYP00000001124 | Prostaglandin F synthase 1-like isoform X1. | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.908 |
| AKR1C8P | STS | ENSPPYP00000002377 | ENSPPYP00000022489 | Prostaglandin F synthase 1-like isoform X1. | STS isoform 1. | 0.910 |
| CR201_G0028793 | CYP17A1 | ENSPPYP00000007772 | ENSPPYP00000003038 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.950 |
| CR201_G0028793 | CYP1A2 | ENSPPYP00000007772 | ENSPPYP00000007537 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.623 |
| CR201_G0028793 | CYP21A2 | ENSPPYP00000007772 | ENSPPYP00000018425 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.948 |
| CR201_G0028793 | CYP2E1 | ENSPPYP00000007772 | ENSPPYP00000003264 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.629 |
| CR201_G0028793 | HSD3B1 | ENSPPYP00000007772 | ENSPPYP00000001124 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.977 |
| CR201_G0028793 | STS | ENSPPYP00000007772 | ENSPPYP00000022489 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | STS isoform 1. | 0.910 |
| CR201_G0048502 | AKR1C8P | ENSPPYP00000024366 | ENSPPYP00000002377 | CYP3A7 isoform 2. | Prostaglandin F synthase 1-like isoform X1. | 0.903 |
| CR201_G0048502 | CYP17A1 | ENSPPYP00000024366 | ENSPPYP00000003038 | CYP3A7 isoform 2. | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.938 |
| CR201_G0048502 | CYP1A1 | ENSPPYP00000024366 | ENSPPYP00000007536 | CYP3A7 isoform 2. | CYP1A1 isoform 1; Belongs to the cytochrome P450 family. | 0.951 |
| CR201_G0048502 | CYP1A2 | ENSPPYP00000024366 | ENSPPYP00000007537 | CYP3A7 isoform 2. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.951 |
| CR201_G0048502 | CYP21A2 | ENSPPYP00000024366 | ENSPPYP00000018425 | CYP3A7 isoform 2. | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.406 |
| CR201_G0048502 | CYP2E1 | ENSPPYP00000024366 | ENSPPYP00000003264 | CYP3A7 isoform 2. | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.490 |
