| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | IRAK1 | ENSPPYP00000004788 | ENSPPYP00000023353 | CD4 isoform 2. | Interleukin 1 receptor associated kinase 1. | 0.533 |
| CD4 | IRAK4 | ENSPPYP00000004788 | ENSPPYP00000005053 | CD4 isoform 2. | IRAK4 isoform 6. | 0.542 |
| CD4 | MYD88 | ENSPPYP00000004788 | ENSPPYP00000015673 | CD4 isoform 2. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.779 |
| CD4 | TLR3 | ENSPPYP00000004788 | ENSPPYP00000017042 | CD4 isoform 2. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.787 |
| CD4 | TLR8 | ENSPPYP00000004788 | ENSPPYP00000022512 | CD4 isoform 2. | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.789 |
| CD4 | TRAF6 | ENSPPYP00000004788 | ENSPPYP00000003845 | CD4 isoform 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.739 |
| CLEC1B | TLR8 | ENSPPYP00000004862 | ENSPPYP00000022512 | C-type lectin domain family 1 member B. | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.773 |
| EIF4H | TLR3 | ENSPPYP00000019605 | ENSPPYP00000017042 | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.449 |
| EIF4H | TLR8 | ENSPPYP00000019605 | ENSPPYP00000022512 | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.736 |
| IRAK1 | CD4 | ENSPPYP00000023353 | ENSPPYP00000004788 | Interleukin 1 receptor associated kinase 1. | CD4 isoform 2. | 0.533 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | MYD88 | ENSPPYP00000023353 | ENSPPYP00000015673 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK1 | TLR3 | ENSPPYP00000023353 | ENSPPYP00000017042 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.787 |
| IRAK1 | TLR8 | ENSPPYP00000023353 | ENSPPYP00000022512 | Interleukin 1 receptor associated kinase 1. | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.969 |
| IRAK1 | TRAF6 | ENSPPYP00000023353 | ENSPPYP00000003845 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| IRAK4 | CD4 | ENSPPYP00000005053 | ENSPPYP00000004788 | IRAK4 isoform 6. | CD4 isoform 2. | 0.542 |
| IRAK4 | IRAK1 | ENSPPYP00000005053 | ENSPPYP00000023353 | IRAK4 isoform 6. | Interleukin 1 receptor associated kinase 1. | 0.999 |
| IRAK4 | MYD88 | ENSPPYP00000005053 | ENSPPYP00000015673 | IRAK4 isoform 6. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK4 | TLR3 | ENSPPYP00000005053 | ENSPPYP00000017042 | IRAK4 isoform 6. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.748 |
| IRAK4 | TLR8 | ENSPPYP00000005053 | ENSPPYP00000022512 | IRAK4 isoform 6. | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.965 |
