node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ACTG1 | ENSPPYP00000019427 | ENSPPYP00000009805 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ACTG1 isoform 10. | 0.999 |
ACTB | CFL1 | ENSPPYP00000019427 | ENSPPYP00000003525 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | 0.996 |
ACTB | PFN1 | ENSPPYP00000019427 | ENSPPYP00000008839 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Profilin; Belongs to the profilin family. | 0.988 |
ACTB | PFN3 | ENSPPYP00000019427 | ENSPPYP00000018006 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Profilin; Belongs to the profilin family. | 0.986 |
ACTB | PFN4 | ENSPPYP00000019427 | ENSPPYP00000014071 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Profilin; Belongs to the profilin family. | 0.989 |
ACTB | TMSB4X | ENSPPYP00000019427 | ENSPPYP00000022513 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. | 0.921 |
ACTG1 | ACTB | ENSPPYP00000009805 | ENSPPYP00000019427 | ACTG1 isoform 10. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.999 |
ACTG1 | CFL1 | ENSPPYP00000009805 | ENSPPYP00000003525 | ACTG1 isoform 10. | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | 0.991 |
ACTG1 | PFN1 | ENSPPYP00000009805 | ENSPPYP00000008839 | ACTG1 isoform 10. | Profilin; Belongs to the profilin family. | 0.821 |
ACTG1 | PFN3 | ENSPPYP00000009805 | ENSPPYP00000018006 | ACTG1 isoform 10. | Profilin; Belongs to the profilin family. | 0.976 |
ACTG1 | PFN4 | ENSPPYP00000009805 | ENSPPYP00000014071 | ACTG1 isoform 10. | Profilin; Belongs to the profilin family. | 0.980 |
ACTG1 | TMSB4X | ENSPPYP00000009805 | ENSPPYP00000022513 | ACTG1 isoform 10. | Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. | 0.940 |
CFL1 | ACTB | ENSPPYP00000003525 | ENSPPYP00000019427 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.996 |
CFL1 | ACTG1 | ENSPPYP00000003525 | ENSPPYP00000009805 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | ACTG1 isoform 10. | 0.991 |
CFL1 | PFN1 | ENSPPYP00000003525 | ENSPPYP00000008839 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | Profilin; Belongs to the profilin family. | 0.892 |
CFL1 | PFN3 | ENSPPYP00000003525 | ENSPPYP00000018006 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | Profilin; Belongs to the profilin family. | 0.804 |
CFL1 | PFN4 | ENSPPYP00000003525 | ENSPPYP00000014071 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | Profilin; Belongs to the profilin family. | 0.789 |
CFL1 | TMSB4X | ENSPPYP00000003525 | ENSPPYP00000022513 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. | Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. | 0.488 |
CR201_G0055900-2 | ILK | ENSPPYP00000024211 | ENSPPYP00000023691 | LIMS1 isoform 8. | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | 0.980 |
CR201_G0055900-2 | TMSB4X | ENSPPYP00000024211 | ENSPPYP00000022513 | LIMS1 isoform 8. | Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. | 0.578 |