MAP3K15 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0002531	CR201_G0024663	ENSPPYP00000010106	ENSPPYP00000013134	TXNDC2 isoform 4.	TXN2 isoform 1.	0.539
CR201_G0002531	MAP3K15	ENSPPYP00000010106	ENSPPYP00000022570	TXNDC2 isoform 4.	MAP3K15 isoform 1.	0.540
CR201_G0024663	CR201_G0002531	ENSPPYP00000013134	ENSPPYP00000010106	TXN2 isoform 1.	TXNDC2 isoform 4.	0.539
CR201_G0024663	ENSPPYP00000016598	ENSPPYP00000013134	ENSPPYP00000016598	TXN2 isoform 1.	annotation not available	0.632
CR201_G0024663	MAP3K15	ENSPPYP00000013134	ENSPPYP00000022570	TXN2 isoform 1.	MAP3K15 isoform 1.	0.518
CR201_G0024663	TXN	ENSPPYP00000013134	ENSPPYP00000021834	TXN2 isoform 1.	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.539
CR201_G0024663	TXNDC8	ENSPPYP00000013134	ENSPPYP00000021835	TXN2 isoform 1.	TXNDC8 isoform 3.	0.539
DAXX	ENSPPYP00000016598	ENSPPYP00000019339	ENSPPYP00000016598	Death domain associated protein.	annotation not available	0.908
DAXX	MAP3K15	ENSPPYP00000019339	ENSPPYP00000022570	Death domain associated protein.	MAP3K15 isoform 1.	0.547
DAXX	TXN	ENSPPYP00000019339	ENSPPYP00000021834	Death domain associated protein.	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.908
ENSPPYP00000016598	CR201_G0024663	ENSPPYP00000016598	ENSPPYP00000013134	annotation not available	TXN2 isoform 1.	0.632
ENSPPYP00000016598	DAXX	ENSPPYP00000016598	ENSPPYP00000019339	annotation not available	Death domain associated protein.	0.908
ENSPPYP00000016598	MAP3K15	ENSPPYP00000016598	ENSPPYP00000022570	annotation not available	MAP3K15 isoform 1.	0.540
ENSPPYP00000016598	TXN	ENSPPYP00000016598	ENSPPYP00000021834	annotation not available	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.900
MAP2K3	MAP2K4	ENSPPYP00000009080	ENSPPYP00000023632	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.917
MAP2K3	MAP2K6	ENSPPYP00000009080	ENSPPYP00000009634	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.997
MAP2K3	MAP3K15	ENSPPYP00000009080	ENSPPYP00000022570	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	MAP3K15 isoform 1.	0.599
MAP2K3	TRAF6	ENSPPYP00000009080	ENSPPYP00000003845	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.656
MAP2K4	MAP2K3	ENSPPYP00000023632	ENSPPYP00000009080	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.917
MAP2K4	MAP2K6	ENSPPYP00000023632	ENSPPYP00000009634	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.923