STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K15MAP3K15 isoform 1. (1148 aa)    
Predicted Functional Partners:
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
   
0.635
MAP2K3
Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.
   
0.623
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
   
0.623
CR201_G0002531
TXNDC2 isoform 4.
    
 0.575
ENSPPYP00000016598
annotation not available
    
 0.575
TXN
Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]
    
 0.575
TXNDC8
TXNDC8 isoform 3.
    
 0.575
DAXX
Death domain associated protein.
    
 
 0.541
NME8
NME8 isoform 1.
   
 0.512
NME9
NME9 isoform 1; Belongs to the NDK family.
    
 0.501
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.