| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B4GALT3 | PRDX4 | ENSPPYP00000000709 | ENSPPYP00000022589 | Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family. | PRDX4 isoform 1. | 0.846 |
| B4GALT3 | TAF11 | ENSPPYP00000000709 | ENSPPYP00000018476 | Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family. | Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively); Belongs to the TAF11 family. | 0.858 |
| ERP44 | PDIA6 | ENSPPYP00000021788 | ENSPPYP00000014123 | ERP44 isoform 1. | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | 0.503 |
| ERP44 | PRDX1 | ENSPPYP00000021788 | ENSPPYP00000001637 | ERP44 isoform 1. | PRDX1 isoform 2. | 0.536 |
| ERP44 | PRDX2 | ENSPPYP00000021788 | ENSPPYP00000024125 | ERP44 isoform 1. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.635 |
| ERP44 | PRDX4 | ENSPPYP00000021788 | ENSPPYP00000022589 | ERP44 isoform 1. | PRDX4 isoform 1. | 0.844 |
| NME8 | PRDX1 | ENSPPYP00000019759 | ENSPPYP00000001637 | NME8 isoform 1. | PRDX1 isoform 2. | 0.763 |
| NME8 | PRDX2 | ENSPPYP00000019759 | ENSPPYP00000024125 | NME8 isoform 1. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.763 |
| NME8 | PRDX4 | ENSPPYP00000019759 | ENSPPYP00000022589 | NME8 isoform 1. | PRDX4 isoform 1. | 0.763 |
| NME8 | PRDX5 | ENSPPYP00000019759 | ENSPPYP00000003590 | NME8 isoform 1. | Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | 0.817 |
| PDIA6 | ERP44 | ENSPPYP00000014123 | ENSPPYP00000021788 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | ERP44 isoform 1. | 0.503 |
| PDIA6 | PRDX1 | ENSPPYP00000014123 | ENSPPYP00000001637 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | PRDX1 isoform 2. | 0.476 |
| PDIA6 | PRDX2 | ENSPPYP00000014123 | ENSPPYP00000024125 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.476 |
| PDIA6 | PRDX4 | ENSPPYP00000014123 | ENSPPYP00000022589 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | PRDX4 isoform 1. | 0.845 |
| PDIA6 | PRDX5 | ENSPPYP00000014123 | ENSPPYP00000003590 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | 0.426 |
| PDIA6 | TXNDC5 | ENSPPYP00000014123 | ENSPPYP00000018134 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | Thioredoxin domain-containing protein 5. | 0.957 |
| PRDX1 | ERP44 | ENSPPYP00000001637 | ENSPPYP00000021788 | PRDX1 isoform 2. | ERP44 isoform 1. | 0.536 |
| PRDX1 | NME8 | ENSPPYP00000001637 | ENSPPYP00000019759 | PRDX1 isoform 2. | NME8 isoform 1. | 0.763 |
| PRDX1 | PDIA6 | ENSPPYP00000001637 | ENSPPYP00000014123 | PRDX1 isoform 2. | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. | 0.476 |
| PRDX1 | PRDX2 | ENSPPYP00000001637 | ENSPPYP00000024125 | PRDX1 isoform 2. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.988 |
